Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin
Background. Coagulase-negative staphylococci (CNS), primarily Staphylococcus epidermidis, predominate in the normal microflora of the eye. However, due to irrational antibiotic therapy, resistant strains are widely distributed among CNS. Aim. To study the sensitivity of the antibiotic resistant C...
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| Format: | Article |
| Language: | English |
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Eco-vector
2020-05-01
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| Series: | Клиническая практика |
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| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/17543/pdf |
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| author | A. S. Khalatyan M. V. Budzinskaya E. G. Kholina M. G. Strakhovskaya N. A. Kolyshkina I. B. Kovalenko V. G. Zhukhovitsky |
| author_facet | A. S. Khalatyan M. V. Budzinskaya E. G. Kholina M. G. Strakhovskaya N. A. Kolyshkina I. B. Kovalenko V. G. Zhukhovitsky |
| author_sort | A. S. Khalatyan |
| collection | DOAJ |
| description | Background. Coagulase-negative staphylococci (CNS), primarily Staphylococcus epidermidis, predominate in the normal microflora of the eye. However, due to irrational antibiotic therapy, resistant strains are widely distributed among CNS.
Aim. To study the sensitivity of the antibiotic resistant CNS isolates to picloxydine, an antiseptic.
Methods. The species, sensitivity to antibiotics and picloxydine were determined for 39 isolates of bacteria obtained from the conjunctival swabs. The cells morphology under the antiseptics influence was studied by electron microscopy.
Results. 33 isolates of S. epidermidis (17 sensitive or resistant to drugs of no more than 2 classes of antibiotics and 16 MDR), 2 S. haemolyticus (1 resistant to 2 classes of antibiotics and 1 MDR), 3 S. hominis (1 sensitive and 2 MDR), 1 S. caprae (MDR) were characterized. In in vitro tests, picloxydine showed high efficiency in suppressing the growth of staphylococci regardless of their sensitivity to antibiotics, as well as bactericidal activity at concentrations of 15.631.2 g/ml, close to those of chlorhexidine. At these concentrations, the antiseptic had a destructive effect on the surface structures of bacterial cells.
Conclusion. The picloxydine antiseptic is equally effective against antibiotic- sensitive and antibiotic-resistant coagulase-negative staphylococci. |
| first_indexed | 2024-03-12T08:43:28Z |
| format | Article |
| id | doaj.art-ffa6aae57b6341d89a1443fc6c1741c1 |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T08:43:28Z |
| publishDate | 2020-05-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-ffa6aae57b6341d89a1443fc6c1741c12023-09-02T16:36:28ZengEco-vectorКлиническая практика2220-30952618-86272020-05-01111424810.17816/clinpract1754316602Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydinA. S. Khalatyan0https://orcid.org/0000-0001-6255-5544M. V. Budzinskaya1https://orcid.org/0000-0002-5507-8775E. G. Kholina2https://orcid.org/0000-0002-5918-5084M. G. Strakhovskaya3https://orcid.org/0000-0002-4571-0431N. A. Kolyshkina4I. B. Kovalenko5https://orcid.org/0000-0002-4949-6591V. G. Zhukhovitsky6Research Institute of Eye DiseasesResearch Institute of Eye DiseasesLomonosov Moscow State UniversityLomonosov Moscow State UniversityFederal Scientific and Clinical Center of Specialized Types of Medical = Care and Medical Technologies of the Federal Medical and Biological Agency of RussiaLomonosov Moscow State UniversityN.F. Gamaleya National Research Center of Epidemiology and MicrobiologyBackground. Coagulase-negative staphylococci (CNS), primarily Staphylococcus epidermidis, predominate in the normal microflora of the eye. However, due to irrational antibiotic therapy, resistant strains are widely distributed among CNS. Aim. To study the sensitivity of the antibiotic resistant CNS isolates to picloxydine, an antiseptic. Methods. The species, sensitivity to antibiotics and picloxydine were determined for 39 isolates of bacteria obtained from the conjunctival swabs. The cells morphology under the antiseptics influence was studied by electron microscopy. Results. 33 isolates of S. epidermidis (17 sensitive or resistant to drugs of no more than 2 classes of antibiotics and 16 MDR), 2 S. haemolyticus (1 resistant to 2 classes of antibiotics and 1 MDR), 3 S. hominis (1 sensitive and 2 MDR), 1 S. caprae (MDR) were characterized. In in vitro tests, picloxydine showed high efficiency in suppressing the growth of staphylococci regardless of their sensitivity to antibiotics, as well as bactericidal activity at concentrations of 15.631.2 g/ml, close to those of chlorhexidine. At these concentrations, the antiseptic had a destructive effect on the surface structures of bacterial cells. Conclusion. The picloxydine antiseptic is equally effective against antibiotic- sensitive and antibiotic-resistant coagulase-negative staphylococci.https://journals.eco-vector.com/clinpractice/article/viewFile/17543/pdfconjunctival microfloracoagulase-negative staphylococciantibiotic resistancepicloxydine |
| spellingShingle | A. S. Khalatyan M. V. Budzinskaya E. G. Kholina M. G. Strakhovskaya N. A. Kolyshkina I. B. Kovalenko V. G. Zhukhovitsky Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin Клиническая практика conjunctival microflora coagulase-negative staphylococci antibiotic resistance picloxydine |
| title | Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin |
| title_full | Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin |
| title_fullStr | Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin |
| title_full_unstemmed | Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin |
| title_short | Sensitivity of antibiotic resistant coagulase-negative staphylococci to antiseptic piсloxydin |
| title_sort | sensitivity of antibiotic resistant coagulase negative staphylococci to antiseptic piсloxydin |
| topic | conjunctival microflora coagulase-negative staphylococci antibiotic resistance picloxydine |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/17543/pdf |
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