Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study
Botulinum toxin type A (BoNT-A) is the treatment of choice for focal spasticity, with a concomitant effect on pain reduction and improvement of quality of life (QoL). Current evidence of its efficacy is based mainly on post stroke spasticity. This study aims to clarify the role of BoNT-A in the cont...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1133390/full |
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| author | Alessio Baricich Alessio Baricich Marco Battaglia Marco Battaglia Daria Cuneo Lucia Cosenza Marzia Millevolte Michela Cosma Mirko Filippetti Stefania Dalise Valentina Azzollini Carmelo Chisari Stefania Spina Nicoletta Cinone Lorenza Scotti Marco Invernizzi Marco Invernizzi Stefano Paolucci Alessandro Picelli Andrea Santamato |
| author_facet | Alessio Baricich Alessio Baricich Marco Battaglia Marco Battaglia Daria Cuneo Lucia Cosenza Marzia Millevolte Michela Cosma Mirko Filippetti Stefania Dalise Valentina Azzollini Carmelo Chisari Stefania Spina Nicoletta Cinone Lorenza Scotti Marco Invernizzi Marco Invernizzi Stefano Paolucci Alessandro Picelli Andrea Santamato |
| author_sort | Alessio Baricich |
| collection | DOAJ |
| description | Botulinum toxin type A (BoNT-A) is the treatment of choice for focal spasticity, with a concomitant effect on pain reduction and improvement of quality of life (QoL). Current evidence of its efficacy is based mainly on post stroke spasticity. This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect in improving all the outcome variables, with different effect persistence over time in relation to the diagnosis and the number of treated sites. Our results support BoNT-A as a modifier of the disability condition and suggest its implementation in the treatment of NSS, delivering a possible starting point to generate diagnosis-specific follow-up programs.Clinical trial identifierNCT04673240. |
| first_indexed | 2024-04-09T19:15:16Z |
| format | Article |
| id | doaj.art-ffa76eefb8224089be907dbb7c7fe8ee |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T19:15:16Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-ffa76eefb8224089be907dbb7c7fe8ee2023-04-06T06:13:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11333901133390Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal studyAlessio Baricich0Alessio Baricich1Marco Battaglia2Marco Battaglia3Daria Cuneo4Lucia Cosenza5Marzia Millevolte6Michela Cosma7Mirko Filippetti8Stefania Dalise9Valentina Azzollini10Carmelo Chisari11Stefania Spina12Nicoletta Cinone13Lorenza Scotti14Marco Invernizzi15Marco Invernizzi16Stefano Paolucci17Alessandro Picelli18Andrea Santamato19Physical and Rehabilitation Medicine, Department of Health Sciences, Università del Piemonte Orientale, Novara, ItalyPhysical and Rehabilitation Medicine, “Ospedale Maggiore della Carità” University Hospital, Novara, ItalyPhysical and Rehabilitation Medicine, Department of Health Sciences, Università del Piemonte Orientale, Novara, ItalyPhysical and Rehabilitation Medicine, “Ospedale Maggiore della Carità” University Hospital, Novara, ItalyPhysical and Rehabilitation Medicine, A.S.L. Vercelli, Vercelli, ItalyRehabilitation Unit, Department of Rehabilitation, “Santi Antonio e Biagio e Cesare Arrigo” National Hospital, Alessandria, ItalyNeurorehabilitation Clinic, Department Neurological Sciences, University Hospital of Ancona, Ancona, ItalyNeuroscience and Rehabilitation Department, Ferrara University Hospital, Ferrara, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, ItalyNeurorehabilitation Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, ItalyNeurorehabilitation Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, ItalyNeurorehabilitation Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, ItalySpasticity and Movement Disorder Unit, Physical Medicine and Rehabilitation, Policlinico Riuniti, University of Foggia, Foggia, ItalySpasticity and Movement Disorder Unit, Physical Medicine and Rehabilitation, Policlinico Riuniti, University of Foggia, Foggia, Italy0Department of Translational Medicine, Unit of Medical Statistics, Università del Piemonte Orientale, Novara, ItalyPhysical and Rehabilitation Medicine, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy1Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Translational Medicine, “Santi Antonio e Biagio e Cesare Arrigo” National Hospital, Alessandria, Italy2IRCCS Fondazione Santa Lucia, Rome, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, ItalySpasticity and Movement Disorder Unit, Physical Medicine and Rehabilitation, Policlinico Riuniti, University of Foggia, Foggia, ItalyBotulinum toxin type A (BoNT-A) is the treatment of choice for focal spasticity, with a concomitant effect on pain reduction and improvement of quality of life (QoL). Current evidence of its efficacy is based mainly on post stroke spasticity. This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect in improving all the outcome variables, with different effect persistence over time in relation to the diagnosis and the number of treated sites. Our results support BoNT-A as a modifier of the disability condition and suggest its implementation in the treatment of NSS, delivering a possible starting point to generate diagnosis-specific follow-up programs.Clinical trial identifierNCT04673240.https://www.frontiersin.org/articles/10.3389/fneur.2023.1133390/fullbotulinum toxinpainspasticitymovement disordersmultiple sclerosisspinal cord injury |
| spellingShingle | Alessio Baricich Alessio Baricich Marco Battaglia Marco Battaglia Daria Cuneo Lucia Cosenza Marzia Millevolte Michela Cosma Mirko Filippetti Stefania Dalise Valentina Azzollini Carmelo Chisari Stefania Spina Nicoletta Cinone Lorenza Scotti Marco Invernizzi Marco Invernizzi Stefano Paolucci Alessandro Picelli Andrea Santamato Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study Frontiers in Neurology botulinum toxin pain spasticity movement disorders multiple sclerosis spinal cord injury |
| title | Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study |
| title_full | Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study |
| title_fullStr | Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study |
| title_full_unstemmed | Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study |
| title_short | Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study |
| title_sort | clinical efficacy of botulinum toxin type a in patients with traumatic brain injury spinal cord injury or multiple sclerosis an observational longitudinal study |
| topic | botulinum toxin pain spasticity movement disorders multiple sclerosis spinal cord injury |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1133390/full |
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