Pre-mRNA splicing-associated diseases and therapies

Pre-mRNA splicing-associated diseases and therapies

Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome. Given the spliceosome's role in shaping the cellular transcriptome, it is not surprising that mutations in the splicing machinery can res...

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Bibliographic Details
Main Authors:	Sierra L. Love, Joseph D. Emerson, Kazunori Koide, Aaron A. Hoskins
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	RNA Biology
Subjects:	spliceosome pre-mrna splicing cancer sma spliceosomopathy sf3b1 snrna splicing inhibitor splicing modulator
Online Access:	http://dx.doi.org/10.1080/15476286.2023.2239601

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