Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Abstract Microglia, the innate immune cells of the brain, are activated by damage or disease. In mouse models of amyotrophic lateral sclerosis (ALS), microglia shift from neurotrophic to neurotoxic states with disease progression. It remains unclear how human microglia change relative to the TAR DNA...

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Bibliographic Details
Main Authors: Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Microglia
TDP-43
CD68
L-ferritin
Online Access:https://doi.org/10.1186/s40478-023-01561-6

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