Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus
People with type 2 diabetes mellitus have increased risk of chronic kidney disease and atherosclerotic cardiovascular disease. Improved care delivery and implementation of guideline-directed medical therapy have contributed to the declining incidence of atherosclerotic cardiovascular disease in high...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2024-03-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-2023-0244.pdf |
| _version_ | 1797221670973341696 |
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| author | Ying-Guat Ooi Tharsini Sarvanandan Nicholas Ken Yoong Hee Quan-Hziung Lim Sharmila S. Paramasivam Jeyakantha Ratnasingam Shireene R. Vethakkan Soo-Kun Lim Lee-Ling Lim |
| author_facet | Ying-Guat Ooi Tharsini Sarvanandan Nicholas Ken Yoong Hee Quan-Hziung Lim Sharmila S. Paramasivam Jeyakantha Ratnasingam Shireene R. Vethakkan Soo-Kun Lim Lee-Ling Lim |
| author_sort | Ying-Guat Ooi |
| collection | DOAJ |
| description | People with type 2 diabetes mellitus have increased risk of chronic kidney disease and atherosclerotic cardiovascular disease. Improved care delivery and implementation of guideline-directed medical therapy have contributed to the declining incidence of atherosclerotic cardiovascular disease in high-income countries. By contrast, the global incidence of chronic kidney disease and associated mortality is either plateaued or increased, leading to escalating direct and indirect medical costs. Given limited resources, better risk stratification approaches to identify people at risk of rapid progression to end-stage kidney disease can reduce therapeutic inertia, facilitate timely interventions and identify the need for early nephrologist referral. Among people with chronic kidney disease G3a and beyond, the kidney failure risk equations (KFRE) have been externally validated and outperformed other risk prediction models. The KFRE can also guide the timing of preparation for kidney replacement therapy with improved healthcare resources planning and may prevent multiple complications and premature mortality among people with chronic kidney disease with and without type 2 diabetes mellitus. The present review summarizes the evidence of KFRE to date and call for future research to validate and evaluate its impact on cardiovascular and mortality outcomes, as well as healthcare resource utilization in multiethnic populations and different healthcare settings. |
| first_indexed | 2024-04-24T13:09:08Z |
| format | Article |
| id | doaj.art-ffaa540a82f94ee8ad4244e6b3542dfe |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-24T13:09:08Z |
| publishDate | 2024-03-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-ffaa540a82f94ee8ad4244e6b3542dfe2024-04-05T06:03:30ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872024-03-0148219620710.4093/dmj.2023.02442801Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes MellitusYing-Guat Ooi0Tharsini Sarvanandan1Nicholas Ken Yoong Hee2Quan-Hziung Lim3Sharmila S. Paramasivam4Jeyakantha Ratnasingam5Shireene R. Vethakkan6Soo-Kun Lim7Lee-Ling Lim8 Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaPeople with type 2 diabetes mellitus have increased risk of chronic kidney disease and atherosclerotic cardiovascular disease. Improved care delivery and implementation of guideline-directed medical therapy have contributed to the declining incidence of atherosclerotic cardiovascular disease in high-income countries. By contrast, the global incidence of chronic kidney disease and associated mortality is either plateaued or increased, leading to escalating direct and indirect medical costs. Given limited resources, better risk stratification approaches to identify people at risk of rapid progression to end-stage kidney disease can reduce therapeutic inertia, facilitate timely interventions and identify the need for early nephrologist referral. Among people with chronic kidney disease G3a and beyond, the kidney failure risk equations (KFRE) have been externally validated and outperformed other risk prediction models. The KFRE can also guide the timing of preparation for kidney replacement therapy with improved healthcare resources planning and may prevent multiple complications and premature mortality among people with chronic kidney disease with and without type 2 diabetes mellitus. The present review summarizes the evidence of KFRE to date and call for future research to validate and evaluate its impact on cardiovascular and mortality outcomes, as well as healthcare resource utilization in multiethnic populations and different healthcare settings.http://e-dmj.org/upload/pdf/dmj-2023-0244.pdfalbuminuriadiabetes mellitusglomerular filtration ratekidney failure, chronicrenal insufficiency, chronicrisk assessment |
| spellingShingle | Ying-Guat Ooi Tharsini Sarvanandan Nicholas Ken Yoong Hee Quan-Hziung Lim Sharmila S. Paramasivam Jeyakantha Ratnasingam Shireene R. Vethakkan Soo-Kun Lim Lee-Ling Lim Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus Diabetes & Metabolism Journal albuminuria diabetes mellitus glomerular filtration rate kidney failure, chronic renal insufficiency, chronic risk assessment |
| title | Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus |
| title_full | Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus |
| title_fullStr | Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus |
| title_short | Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus |
| title_sort | risk prediction and management of chronic kidney disease in people living with type 2 diabetes mellitus |
| topic | albuminuria diabetes mellitus glomerular filtration rate kidney failure, chronic renal insufficiency, chronic risk assessment |
| url | http://e-dmj.org/upload/pdf/dmj-2023-0244.pdf |
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