Cortical thickness analysis in operculo-insular epilepsy
Background: In temporal lobe epilepsy (TLE), advanced neuroimaging techniques reveal anomalies extending beyond the temporal lobe such as thinning of fronto-central cortices. Operculo-insular epilepsy (OIE) is an under-recognized and poorly characterized condition with the potential of mimicking TLE...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
|
| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301797 |
| _version_ | 1828378556127772672 |
|---|---|
| author | Sami Obaid Alan Tucholka Jimmy Ghaziri Pierre-Marc Jodoin Félix Morency Maxime Descoteaux Alain Bouthillier Dang K. Nguyen |
| author_facet | Sami Obaid Alan Tucholka Jimmy Ghaziri Pierre-Marc Jodoin Félix Morency Maxime Descoteaux Alain Bouthillier Dang K. Nguyen |
| author_sort | Sami Obaid |
| collection | DOAJ |
| description | Background: In temporal lobe epilepsy (TLE), advanced neuroimaging techniques reveal anomalies extending beyond the temporal lobe such as thinning of fronto-central cortices. Operculo-insular epilepsy (OIE) is an under-recognized and poorly characterized condition with the potential of mimicking TLE. In this work, we investigated insular and extra-insular cortical thickness (CT) changes in OIE. Methods: All participants (14 patients with refractory OIE, 9 age- and sex-matched patients with refractory TLE and 26 healthy controls) underwent a T1-weighted acquisition on a 3 T MRI. Anatomical images were processed with Advanced Normalization Tools. Between-group analysis of CT was performed using a two-sided t-test (threshold of p < 0.05 after correction for multiple comparisons; cut-off threshold of 250 voxels) between (i) patients with OIE vs TLE, and (ii) patients with OIE vs healthy controls. Results: Significant widespread thinning was observed in OIE patients as compared with healthy controls mainly in the ipsilateral insula, peri-rolandic region, orbito-frontal area, mesiotemporal structures and lateral temporal neocortex. Contralateral cortical shrinkage followed a similar albeit milder and less diffuse pattern.The CT of OIE patients was equal or reduced relative to the TLE group for every cortical region analyzed. Thinning was observed diffusely in OIE patients, predominantly inboth insulae and the ipsilateral occipito-temporal area. Conclusion: Our results reveal structural anomalies extending beyond the operculo-insular area in OIE. Keywords: Epilepsy, Insula, Operculum, Cortical thickness |
| first_indexed | 2024-04-14T08:28:35Z |
| format | Article |
| id | doaj.art-ffac8fa02b7d485494f1bbe6c2b5a439 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-14T08:28:35Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ffac8fa02b7d485494f1bbe6c2b5a4392022-12-22T02:03:58ZengElsevierNeuroImage: Clinical2213-15822018-01-0119727733Cortical thickness analysis in operculo-insular epilepsySami Obaid0Alan Tucholka1Jimmy Ghaziri2Pierre-Marc Jodoin3Félix Morency4Maxime Descoteaux5Alain Bouthillier6Dang K. Nguyen7Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Service de Neurochirurgie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.Barcelona Beta Brain Research Center, Foundation Pasqual Maragall, Barcelona, SpainCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Département de psychologie, Université du Québec à Montréal, Montréal, Québec, CanadaSherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, Québec, CanadaSherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, Québec, CanadaSherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, Québec, CanadaService de Neurochirurgie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Service de Neurologie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Corresponding author at: CHUM, 1000Saint-Denis, Montreal, Quebec H2X 0C1, Canada.Background: In temporal lobe epilepsy (TLE), advanced neuroimaging techniques reveal anomalies extending beyond the temporal lobe such as thinning of fronto-central cortices. Operculo-insular epilepsy (OIE) is an under-recognized and poorly characterized condition with the potential of mimicking TLE. In this work, we investigated insular and extra-insular cortical thickness (CT) changes in OIE. Methods: All participants (14 patients with refractory OIE, 9 age- and sex-matched patients with refractory TLE and 26 healthy controls) underwent a T1-weighted acquisition on a 3 T MRI. Anatomical images were processed with Advanced Normalization Tools. Between-group analysis of CT was performed using a two-sided t-test (threshold of p < 0.05 after correction for multiple comparisons; cut-off threshold of 250 voxels) between (i) patients with OIE vs TLE, and (ii) patients with OIE vs healthy controls. Results: Significant widespread thinning was observed in OIE patients as compared with healthy controls mainly in the ipsilateral insula, peri-rolandic region, orbito-frontal area, mesiotemporal structures and lateral temporal neocortex. Contralateral cortical shrinkage followed a similar albeit milder and less diffuse pattern.The CT of OIE patients was equal or reduced relative to the TLE group for every cortical region analyzed. Thinning was observed diffusely in OIE patients, predominantly inboth insulae and the ipsilateral occipito-temporal area. Conclusion: Our results reveal structural anomalies extending beyond the operculo-insular area in OIE. Keywords: Epilepsy, Insula, Operculum, Cortical thicknesshttp://www.sciencedirect.com/science/article/pii/S2213158218301797 |
| spellingShingle | Sami Obaid Alan Tucholka Jimmy Ghaziri Pierre-Marc Jodoin Félix Morency Maxime Descoteaux Alain Bouthillier Dang K. Nguyen Cortical thickness analysis in operculo-insular epilepsy NeuroImage: Clinical |
| title | Cortical thickness analysis in operculo-insular epilepsy |
| title_full | Cortical thickness analysis in operculo-insular epilepsy |
| title_fullStr | Cortical thickness analysis in operculo-insular epilepsy |
| title_full_unstemmed | Cortical thickness analysis in operculo-insular epilepsy |
| title_short | Cortical thickness analysis in operculo-insular epilepsy |
| title_sort | cortical thickness analysis in operculo insular epilepsy |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301797 |
| work_keys_str_mv | AT samiobaid corticalthicknessanalysisinoperculoinsularepilepsy AT alantucholka corticalthicknessanalysisinoperculoinsularepilepsy AT jimmyghaziri corticalthicknessanalysisinoperculoinsularepilepsy AT pierremarcjodoin corticalthicknessanalysisinoperculoinsularepilepsy AT felixmorency corticalthicknessanalysisinoperculoinsularepilepsy AT maximedescoteaux corticalthicknessanalysisinoperculoinsularepilepsy AT alainbouthillier corticalthicknessanalysisinoperculoinsularepilepsy AT dangknguyen corticalthicknessanalysisinoperculoinsularepilepsy |