Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study
Abstract Objection Inflammatory conditions and immune disorders may worsen the prognosis of chronic heart failure (CHF) patients. The aim of this study was to evaluate the prognostic value of a new indicator, C-NLR, composed of C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), for t...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-024-03714-4 |
| _version_ | 1797350173964238848 |
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| author | Fazhi Yang Lihua Zhang Wei Huang Dajin Liu Yunhong Yang Wenyi Gu Tao Shi Sirui Yang Lixing Chen |
| author_facet | Fazhi Yang Lihua Zhang Wei Huang Dajin Liu Yunhong Yang Wenyi Gu Tao Shi Sirui Yang Lixing Chen |
| author_sort | Fazhi Yang |
| collection | DOAJ |
| description | Abstract Objection Inflammatory conditions and immune disorders may worsen the prognosis of chronic heart failure (CHF) patients. The aim of this study was to evaluate the prognostic value of a new indicator, C-NLR, composed of C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), for the risk of all-cause mortality in HF patients with different ejection fractions. Methods A total of 1221 CHF patients admitted to the First Affiliated Hospital of Kunming Medical University from January 2017 to October 2021 were enrolled in this study. All patients were divided into 2 groups according to the median C-NLR. Kaplan–Meier survival curves were used to compare the all-cause mortality among CHF patients with different ejection fractions. Cox proportional hazards analysis was used to evaluate the relationships between variables and mortality. The predictive value of the C-NLR was assessed by using receiver operating characteristic (ROC) analyses. Results We collected data from 1192 patients with CHF. Kaplan–Meier survival analysis revealed that patients with low LCR levels had better overall survival (OS). After multivariate adjustment Cox proportional hazards analysis, the level of C-NLR was still independently related to mortality. Conclusions C-NLR was a competent independent predictor in HF with different ejection fractions, and routine measurement of C-NLR would help clinical doctors identify patients with a poor prognosis. |
| first_indexed | 2024-03-08T12:40:56Z |
| format | Article |
| id | doaj.art-ffacb8ada2ef4c94b521a7aa7db7d3ec |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-08T12:40:56Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-ffacb8ada2ef4c94b521a7aa7db7d3ec2024-01-21T12:09:41ZengBMCBMC Cardiovascular Disorders1471-22612024-01-0124111210.1186/s12872-024-03714-4Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective studyFazhi Yang0Lihua Zhang1Wei Huang2Dajin Liu3Yunhong Yang4Wenyi Gu5Tao Shi6Sirui Yang7Lixing Chen8Department of Cardiology, Kunming Medical University First Affilliated HospitalDepartment of General Medicine, Kunming Medical University First Affilliated HospitalDepartment of Geriatrics, The Third People’s Hospital of Yunnan ProvinceMedical Records and Statistics Department, Kunming Medical University First Affilliated HospitalDepartment of Cardiology, Kunming Medical University First Affilliated HospitalDepartment of Cardiology, Kunming Medical University First Affilliated HospitalDepartment of Cardiology, Kunming Medical University First Affilliated HospitalDepartment of Cardiology, Kunming Medical University First Affilliated HospitalDepartment of Cardiology, Kunming Medical University First Affilliated HospitalAbstract Objection Inflammatory conditions and immune disorders may worsen the prognosis of chronic heart failure (CHF) patients. The aim of this study was to evaluate the prognostic value of a new indicator, C-NLR, composed of C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), for the risk of all-cause mortality in HF patients with different ejection fractions. Methods A total of 1221 CHF patients admitted to the First Affiliated Hospital of Kunming Medical University from January 2017 to October 2021 were enrolled in this study. All patients were divided into 2 groups according to the median C-NLR. Kaplan–Meier survival curves were used to compare the all-cause mortality among CHF patients with different ejection fractions. Cox proportional hazards analysis was used to evaluate the relationships between variables and mortality. The predictive value of the C-NLR was assessed by using receiver operating characteristic (ROC) analyses. Results We collected data from 1192 patients with CHF. Kaplan–Meier survival analysis revealed that patients with low LCR levels had better overall survival (OS). After multivariate adjustment Cox proportional hazards analysis, the level of C-NLR was still independently related to mortality. Conclusions C-NLR was a competent independent predictor in HF with different ejection fractions, and routine measurement of C-NLR would help clinical doctors identify patients with a poor prognosis.https://doi.org/10.1186/s12872-024-03714-4Heart failureInflammationImmunityPrognosisEjection fraction |
| spellingShingle | Fazhi Yang Lihua Zhang Wei Huang Dajin Liu Yunhong Yang Wenyi Gu Tao Shi Sirui Yang Lixing Chen Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study BMC Cardiovascular Disorders Heart failure Inflammation Immunity Prognosis Ejection fraction |
| title | Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study |
| title_full | Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study |
| title_fullStr | Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study |
| title_full_unstemmed | Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study |
| title_short | Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective study |
| title_sort | clinical prognostic impact of c nlr in heart failure patients with different ejection fractions a retrospective study |
| topic | Heart failure Inflammation Immunity Prognosis Ejection fraction |
| url | https://doi.org/10.1186/s12872-024-03714-4 |
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