Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study
Abstract Background Commencing work at an early age has been linked to various risk factors for coronary heart disease (CHD), such as shift work and intensive job strain. However, the relationship between starting work too early and CHD risk remains largely unclear. We examined the association betwe...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-023-17034-3 |
| _version_ | 1797636657940267008 |
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| author | Zenghui Zhang Chuanrui Zeng Zhiteng Chen Pinming Liu Jingwei Gao Qi Guo Maoxiong Wu Wanbing He Qingyuan Gao Dachuan Guo Xiaotian Liang Zegui Huang Jingfeng Wang Haifeng Zhang Yangxin Chen |
| author_facet | Zenghui Zhang Chuanrui Zeng Zhiteng Chen Pinming Liu Jingwei Gao Qi Guo Maoxiong Wu Wanbing He Qingyuan Gao Dachuan Guo Xiaotian Liang Zegui Huang Jingfeng Wang Haifeng Zhang Yangxin Chen |
| author_sort | Zenghui Zhang |
| collection | DOAJ |
| description | Abstract Background Commencing work at an early age has been linked to various risk factors for coronary heart disease (CHD), such as shift work and intensive job strain. However, the relationship between starting work too early and CHD risk remains largely unclear. We examined the association between age at job initiation and the risk of CHD. Methods UK Biobank participants aged 38 to 70 years without cardiovascular disease who provided data on their age at job initiation were included. The primary outcome was CHD, which was ascertained using hospital and death records. The hazard ratios (HRs) and 95% confidence interval (CIs) for the association between age at job initiation and CHD were calculated using multivariable Cox regression. Results Of the 501,971 participants, 114,418 eligible participants were included in the final analysis. The median age at job initiation was 19.0 years. During the mean follow-up of 12.6 years, 6,130 (5.4%) first CHD events occurred. We observed that age at job initiation was inversely associated with CHD (HR 0.98, 95% CI 0.97–0.99), and the association was potentially J-shaped. The HRs for the < 17-year, 17–18-year, and 19–21-year age groups were 1.29 (95%CI 1.18–1.41), 1.12 (95% CI 1.03–1.22) and 1.05 (95% CI 0.97–1.14), respectively, compared with those of the ≥ 22-year group. Conclusions Age at job initiation was associated with incident CHD, which was independent of socioeconomic status. Participants who commenced employment before the age of 19 years exhibited a higher risk of developing CHD later in adulthood. |
| first_indexed | 2024-03-11T12:38:14Z |
| format | Article |
| id | doaj.art-ffad6a8fd4d742eeb0a5b3bf306b66d5 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-11T12:38:14Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-ffad6a8fd4d742eeb0a5b3bf306b66d52023-11-05T12:31:30ZengBMCBMC Public Health1471-24582023-10-0123111110.1186/s12889-023-17034-3Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort studyZenghui Zhang0Chuanrui Zeng1Zhiteng Chen2Pinming Liu3Jingwei Gao4Qi Guo5Maoxiong Wu6Wanbing He7Qingyuan Gao8Dachuan Guo9Xiaotian Liang10Zegui Huang11Jingfeng Wang12Haifeng Zhang13Yangxin Chen14Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityAbstract Background Commencing work at an early age has been linked to various risk factors for coronary heart disease (CHD), such as shift work and intensive job strain. However, the relationship between starting work too early and CHD risk remains largely unclear. We examined the association between age at job initiation and the risk of CHD. Methods UK Biobank participants aged 38 to 70 years without cardiovascular disease who provided data on their age at job initiation were included. The primary outcome was CHD, which was ascertained using hospital and death records. The hazard ratios (HRs) and 95% confidence interval (CIs) for the association between age at job initiation and CHD were calculated using multivariable Cox regression. Results Of the 501,971 participants, 114,418 eligible participants were included in the final analysis. The median age at job initiation was 19.0 years. During the mean follow-up of 12.6 years, 6,130 (5.4%) first CHD events occurred. We observed that age at job initiation was inversely associated with CHD (HR 0.98, 95% CI 0.97–0.99), and the association was potentially J-shaped. The HRs for the < 17-year, 17–18-year, and 19–21-year age groups were 1.29 (95%CI 1.18–1.41), 1.12 (95% CI 1.03–1.22) and 1.05 (95% CI 0.97–1.14), respectively, compared with those of the ≥ 22-year group. Conclusions Age at job initiation was associated with incident CHD, which was independent of socioeconomic status. Participants who commenced employment before the age of 19 years exhibited a higher risk of developing CHD later in adulthood.https://doi.org/10.1186/s12889-023-17034-3Young workerRisk factorCoronary heart diseaseEarly work exposure |
| spellingShingle | Zenghui Zhang Chuanrui Zeng Zhiteng Chen Pinming Liu Jingwei Gao Qi Guo Maoxiong Wu Wanbing He Qingyuan Gao Dachuan Guo Xiaotian Liang Zegui Huang Jingfeng Wang Haifeng Zhang Yangxin Chen Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study BMC Public Health Young worker Risk factor Coronary heart disease Early work exposure |
| title | Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study |
| title_full | Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study |
| title_fullStr | Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study |
| title_full_unstemmed | Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study |
| title_short | Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study |
| title_sort | age at job initiation and risk of coronary heart disease findings from the uk biobank cohort study |
| topic | Young worker Risk factor Coronary heart disease Early work exposure |
| url | https://doi.org/10.1186/s12889-023-17034-3 |
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