Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?
Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecule...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1000972/full |
| _version_ | 1818049154680619008 |
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| author | Debora B. Scariot Austeja Staneviciute Jennifer Zhu Xiaomo Li Xiaomo Li Evan A. Scott David M. Engman |
| author_facet | Debora B. Scariot Austeja Staneviciute Jennifer Zhu Xiaomo Li Xiaomo Li Evan A. Scott David M. Engman |
| author_sort | Debora B. Scariot |
| collection | DOAJ |
| description | Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment. |
| first_indexed | 2024-12-10T10:33:04Z |
| format | Article |
| id | doaj.art-ffadb00431674104804c4868d304f8a2 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T10:33:04Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-ffadb00431674104804c4868d304f8a22022-12-22T01:52:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-09-011210.3389/fcimb.2022.10009721000972Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?Debora B. Scariot0Austeja Staneviciute1Jennifer Zhu2Xiaomo Li3Xiaomo Li4Evan A. Scott5David M. Engman6Department of Biomedical Engineering, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, Evanston and Chicago, IL, United StatesDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, Evanston and Chicago, IL, United StatesDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, Evanston and Chicago, IL, United StatesDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Pathology, Northwestern University, Chicago, IL, United StatesDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, Evanston and Chicago, IL, United StatesDepartment of Pathology, Northwestern University, Chicago, IL, United StatesNanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1000972/fullChagas diseaseleishmaniasisnanotechnologydrug delivery systemstrypanosomatids |
| spellingShingle | Debora B. Scariot Austeja Staneviciute Jennifer Zhu Xiaomo Li Xiaomo Li Evan A. Scott David M. Engman Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? Frontiers in Cellular and Infection Microbiology Chagas disease leishmaniasis nanotechnology drug delivery systems trypanosomatids |
| title | Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? |
| title_full | Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? |
| title_fullStr | Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? |
| title_full_unstemmed | Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? |
| title_short | Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? |
| title_sort | leishmaniasis and chagas disease is there hope in nanotechnology to fight neglected tropical diseases |
| topic | Chagas disease leishmaniasis nanotechnology drug delivery systems trypanosomatids |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1000972/full |
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