Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning
Objective Carbon monoxide (CO) activates intravascular neutrophils through platelet-neutrophil aggregates, which cause neutrophil degranulation. This process causes the release of myeloperoxidase (MPO), proteases, and reactive oxygen species. The MPO index (MPXI) is a newly reported inflammatory mar...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2022-09-01
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| Series: | Clinical and Experimental Emergency Medicine |
| Subjects: | |
| Online Access: | http://ceemjournal.org/upload/pdf/ceem-22-216.pdf |
| _version_ | 1828006204472819712 |
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| author | Joong Seok Moon Sung Hwa Kim Yong Sung Cha |
| author_facet | Joong Seok Moon Sung Hwa Kim Yong Sung Cha |
| author_sort | Joong Seok Moon |
| collection | DOAJ |
| description | Objective Carbon monoxide (CO) activates intravascular neutrophils through platelet-neutrophil aggregates, which cause neutrophil degranulation. This process causes the release of myeloperoxidase (MPO), proteases, and reactive oxygen species. The MPO index (MPXI) is a newly reported inflammatory marker that reflects the MPO level within neutrophils. The MPXI in conditions associated with neutrophil activation depends on the net effect of azurophil degranulation. This study aimed to determine whether the MPXI can predict neurocognitive prognosis 1 month after acute CO poisoning. Methods We included patients aged ≥16 years with acute CO poisoning from a cohort at a single tertiary academic hospital in Wonju, Korea, between January 2010 and May 2021. Data from 699 patients were analyzed. The neurocognitive outcome was assessed using Global Deterioration Scale scores and classified as favorable (score, 1–3 points) or poor (score, 4–7 points). The MPXI was determined within 1 hour of arrival to the emergency department. Results Among the 699 patients, 52 (7.4%) showed poor outcomes. The median MPXI of the patients in the poor outcome group was higher than that of the favorable outcome group (0.85 vs. 0.2, P=0.189). However, a significant difference was not found between the favorable and poor outcome groups, and MPXI was not a significant variable in multivariate logistic regression. Conclusion The MPXI evaluated in the emergency department did not differ based on neurocognitive outcome at 1 month after acute CO poisoning. |
| first_indexed | 2024-04-10T07:53:46Z |
| format | Article |
| id | doaj.art-ffaec2f9fbfa4b9dacfae4bb6e86fe84 |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:53:46Z |
| publishDate | 2022-09-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-ffaec2f9fbfa4b9dacfae4bb6e86fe842023-02-23T07:13:44ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252022-09-019323023710.15441/ceem.22.216406Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoningJoong Seok Moon0Sung Hwa Kim1Yong Sung Cha2 Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Biostatistics and Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, KoreaObjective Carbon monoxide (CO) activates intravascular neutrophils through platelet-neutrophil aggregates, which cause neutrophil degranulation. This process causes the release of myeloperoxidase (MPO), proteases, and reactive oxygen species. The MPO index (MPXI) is a newly reported inflammatory marker that reflects the MPO level within neutrophils. The MPXI in conditions associated with neutrophil activation depends on the net effect of azurophil degranulation. This study aimed to determine whether the MPXI can predict neurocognitive prognosis 1 month after acute CO poisoning. Methods We included patients aged ≥16 years with acute CO poisoning from a cohort at a single tertiary academic hospital in Wonju, Korea, between January 2010 and May 2021. Data from 699 patients were analyzed. The neurocognitive outcome was assessed using Global Deterioration Scale scores and classified as favorable (score, 1–3 points) or poor (score, 4–7 points). The MPXI was determined within 1 hour of arrival to the emergency department. Results Among the 699 patients, 52 (7.4%) showed poor outcomes. The median MPXI of the patients in the poor outcome group was higher than that of the favorable outcome group (0.85 vs. 0.2, P=0.189). However, a significant difference was not found between the favorable and poor outcome groups, and MPXI was not a significant variable in multivariate logistic regression. Conclusion The MPXI evaluated in the emergency department did not differ based on neurocognitive outcome at 1 month after acute CO poisoning.http://ceemjournal.org/upload/pdf/ceem-22-216.pdfcarbon monoxide poisoningprognosiscognitive dysfunctionbiomarkers |
| spellingShingle | Joong Seok Moon Sung Hwa Kim Yong Sung Cha Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning Clinical and Experimental Emergency Medicine carbon monoxide poisoning prognosis cognitive dysfunction biomarkers |
| title | Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| title_full | Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| title_fullStr | Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| title_full_unstemmed | Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| title_short | Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| title_sort | prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning |
| topic | carbon monoxide poisoning prognosis cognitive dysfunction biomarkers |
| url | http://ceemjournal.org/upload/pdf/ceem-22-216.pdf |
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