Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets
Post-weaning diarrhea of piglets is associated with gut microbiota dysbiosis and intestinal pathogen infection. Recent studies have shown that Lactococcus lactis (L.lactis) could help suppress pathogen infection. This study aimed to investigate the effects of L.lactis on various factors related to g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.713256/full |
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| author | Dongming Yu Dongming Yu Yaoyao Xia Liangpeng Ge Bie Tan Bie Tan Bie Tan Bie Tan Shuai Chen Shuai Chen Shuai Chen Shuai Chen |
| author_facet | Dongming Yu Dongming Yu Yaoyao Xia Liangpeng Ge Bie Tan Bie Tan Bie Tan Bie Tan Shuai Chen Shuai Chen Shuai Chen Shuai Chen |
| author_sort | Dongming Yu |
| collection | DOAJ |
| description | Post-weaning diarrhea of piglets is associated with gut microbiota dysbiosis and intestinal pathogen infection. Recent studies have shown that Lactococcus lactis (L.lactis) could help suppress pathogen infection. This study aimed to investigate the effects of L.lactis on various factors related to growth and immunity in weaning piglets. The results showed that L.lactis improved the growth performance, regulated the amino acid profile (for example, increasing serum tryptophan and ileal mucosal cystine) and the intestinal GABAergic system (including inhibiting ileal gene expression of SLC6A13, GABAAρ1, π, θ, and γ1, and promoting ileal GABAAα5 expression). L.lactis also modulated intestinal immunity by promoting jejunal interleukin 17, 18, 22, ileal toll-like receptor 2, 5, 6, and myeloid differentiation primary response protein 88 gene expression while inhibiting jejunal interferon-γ and ileal interleukin 22 expressions. L.lactis highly affected the intestinal microbiota by improving the beta diversity of gut microbiota and the relative abundance of Halomonas and Shewanella. In conclusion, L.lactis improved the growth performance and regulated amino acid profiles, intestinal immunity and microbiota in weaning piglets. |
| first_indexed | 2024-12-14T22:54:38Z |
| format | Article |
| id | doaj.art-ffaef199bc5948a589571bf9846fd4ba |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-14T22:54:38Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-ffaef199bc5948a589571bf9846fd4ba2022-12-21T22:44:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-08-01810.3389/fnut.2021.713256713256Effects of Lactococcus lactis on the Intestinal Functions in Weaning PigletsDongming Yu0Dongming Yu1Yaoyao Xia2Liangpeng Ge3Bie Tan4Bie Tan5Bie Tan6Bie Tan7Shuai Chen8Shuai Chen9Shuai Chen10Shuai Chen11Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaGuangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaGuangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, ChinaLaboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Changsha, ChinaNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, ChinaInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, ChinaGuangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, ChinaLaboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Changsha, ChinaNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, ChinaInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, ChinaPost-weaning diarrhea of piglets is associated with gut microbiota dysbiosis and intestinal pathogen infection. Recent studies have shown that Lactococcus lactis (L.lactis) could help suppress pathogen infection. This study aimed to investigate the effects of L.lactis on various factors related to growth and immunity in weaning piglets. The results showed that L.lactis improved the growth performance, regulated the amino acid profile (for example, increasing serum tryptophan and ileal mucosal cystine) and the intestinal GABAergic system (including inhibiting ileal gene expression of SLC6A13, GABAAρ1, π, θ, and γ1, and promoting ileal GABAAα5 expression). L.lactis also modulated intestinal immunity by promoting jejunal interleukin 17, 18, 22, ileal toll-like receptor 2, 5, 6, and myeloid differentiation primary response protein 88 gene expression while inhibiting jejunal interferon-γ and ileal interleukin 22 expressions. L.lactis highly affected the intestinal microbiota by improving the beta diversity of gut microbiota and the relative abundance of Halomonas and Shewanella. In conclusion, L.lactis improved the growth performance and regulated amino acid profiles, intestinal immunity and microbiota in weaning piglets.https://www.frontiersin.org/articles/10.3389/fnut.2021.713256/fullLactococcus lactisamino acidweaning pigletintestinal immunitygut microbiota |
| spellingShingle | Dongming Yu Dongming Yu Yaoyao Xia Liangpeng Ge Bie Tan Bie Tan Bie Tan Bie Tan Shuai Chen Shuai Chen Shuai Chen Shuai Chen Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets Frontiers in Nutrition Lactococcus lactis amino acid weaning piglet intestinal immunity gut microbiota |
| title | Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets |
| title_full | Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets |
| title_fullStr | Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets |
| title_full_unstemmed | Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets |
| title_short | Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets |
| title_sort | effects of lactococcus lactis on the intestinal functions in weaning piglets |
| topic | Lactococcus lactis amino acid weaning piglet intestinal immunity gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.713256/full |
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