Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice

Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice

Background: MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role of miR-222 in the regulation of...

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Bibliographic Details
Main Authors: Ming Su, Zhiguo Chen, Changxin Wang, Lei Song, Yubao Zou, Lianfeng Zhang, Rutai Hui, Jizheng Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
miR-222
Heart failure
Autophagy
mTOR
Online Access:http://www.karger.com/Article/FullText/447853

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