Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study

Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study

Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Experimental studies indicate that intermittent hypoxia (IH) mimicking OSA induces oxidative stress and inflamm...

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Bibliographic Details
Main Authors: Núria Farré, Jorge Otero, Bryan Falcones, Marta Torres, Ignasi Jorba, David Gozal, Isaac Almendros, Ramon Farré, Daniel Navajas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
atomic force microscopy
tensile test
heart mechanics
myocardial stiffness
ventricular strain
obstructive sleep apnea
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01143/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01143/full

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