Rifampicin-Induced Concomitant Renal Injury and Hepatitis
Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during treatment of tuberculosis can have v...
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JCDR Research and Publications Private Limited
2016-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8578/21030_CE[Ra]_F(P)_PF1(ASEKAK)_PFA(AK).pdf |
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| author | Bharti Chogtu Vyshak Uddur Surendra Rahul Magazine Preetam Rajgopal Acharya Devesh Bhaskar Yerrapragada |
| author_facet | Bharti Chogtu Vyshak Uddur Surendra Rahul Magazine Preetam Rajgopal Acharya Devesh Bhaskar Yerrapragada |
| author_sort | Bharti Chogtu |
| collection | DOAJ |
| description | Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular
treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during
treatment of tuberculosis can have varied aetiologies: drug induced, concomitant viral infection, pre-existing co-morbidities or a
combination of these. Since, hepatitis and/or renal insufficiency can be life threatening a prompt diagnosis is warranted, where drugs
should be kept as one of the important cause. Identifying the drug helps in treating hepatitis and/or renal insufficiency along with helping
the physician to change the combination of ATT regimen. Rifampicin is one of the most important first line drugs in the treatment of
tuberculosis. Hepatitis, epigastric distress, anaemia, thrombocytopenia, and interstitial nephritis are reported adverse drug reactions to
rifampicin. As per literature rifampicin induced renal toxicity is usually seen on rifampicin re-exposure, or rifampicin administration on
alternate days, both being present in this case. Here we are reporting a case of ATT induced renal failure with concomitant hepatitis
where rifampicin was suspected to be the cause. |
| first_indexed | 2024-12-11T16:42:03Z |
| format | Article |
| id | doaj.art-ffb723d06ae24487b1b282ab2fe71c7e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T16:42:03Z |
| publishDate | 2016-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-ffb723d06ae24487b1b282ab2fe71c7e2022-12-22T00:58:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-09-01109OD18OD1910.7860/JCDR/2016/21030.8578Rifampicin-Induced Concomitant Renal Injury and HepatitisBharti Chogtu0Vyshak Uddur Surendra1Rahul Magazine2Preetam Rajgopal Acharya3Devesh Bhaskar Yerrapragada4Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Postgraduate Student, Department of Pulmonary Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Professor, Department of Pulmonary Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Associate Professor, Department of Pulmonary Medicine, Kasturba Medical College, Mangalore, Manipal University, Karnataka, India.Student, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during treatment of tuberculosis can have varied aetiologies: drug induced, concomitant viral infection, pre-existing co-morbidities or a combination of these. Since, hepatitis and/or renal insufficiency can be life threatening a prompt diagnosis is warranted, where drugs should be kept as one of the important cause. Identifying the drug helps in treating hepatitis and/or renal insufficiency along with helping the physician to change the combination of ATT regimen. Rifampicin is one of the most important first line drugs in the treatment of tuberculosis. Hepatitis, epigastric distress, anaemia, thrombocytopenia, and interstitial nephritis are reported adverse drug reactions to rifampicin. As per literature rifampicin induced renal toxicity is usually seen on rifampicin re-exposure, or rifampicin administration on alternate days, both being present in this case. Here we are reporting a case of ATT induced renal failure with concomitant hepatitis where rifampicin was suspected to be the cause.https://jcdr.net/articles/PDF/8578/21030_CE[Ra]_F(P)_PF1(ASEKAK)_PFA(AK).pdfanti tubercular drugsliver function testsserum creatinineserum urea |
| spellingShingle | Bharti Chogtu Vyshak Uddur Surendra Rahul Magazine Preetam Rajgopal Acharya Devesh Bhaskar Yerrapragada Rifampicin-Induced Concomitant Renal Injury and Hepatitis Journal of Clinical and Diagnostic Research anti tubercular drugs liver function tests serum creatinine serum urea |
| title | Rifampicin-Induced Concomitant Renal Injury and Hepatitis |
| title_full | Rifampicin-Induced Concomitant Renal Injury and Hepatitis |
| title_fullStr | Rifampicin-Induced Concomitant Renal Injury and Hepatitis |
| title_full_unstemmed | Rifampicin-Induced Concomitant Renal Injury and Hepatitis |
| title_short | Rifampicin-Induced Concomitant Renal Injury and Hepatitis |
| title_sort | rifampicin induced concomitant renal injury and hepatitis |
| topic | anti tubercular drugs liver function tests serum creatinine serum urea |
| url | https://jcdr.net/articles/PDF/8578/21030_CE[Ra]_F(P)_PF1(ASEKAK)_PFA(AK).pdf |
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