Spontaneous Tumor Lysis Syndrome
Tumor lysis syndrome (TLS) is a hemato-oncological emergency characterized by metabolic and electrolyte imbalances which are associated with disintegrating tumor cells. The syndrome is frequently observed when starting cytotoxic treatment of hematological malignancies, while the incidence of spontan...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2020-09-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/509643 |
| _version_ | 1818264913610539008 |
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| author | Wiebke Wesemüller Christian Taverna |
| author_facet | Wiebke Wesemüller Christian Taverna |
| author_sort | Wiebke Wesemüller |
| collection | DOAJ |
| description | Tumor lysis syndrome (TLS) is a hemato-oncological emergency characterized by metabolic and electrolyte imbalances which are associated with disintegrating tumor cells. The syndrome is frequently observed when starting cytotoxic treatment of hematological malignancies, while the incidence of spontaneous tumor lysis prior to the start of tumor therapy is rare. Here, we present a case of spontaneous TLS in a male patient who was referred with unspecific symptoms and suspected metastatic malignancy. He developed acute renal failure before the diagnosis of a high-grade B-cell lymphoma (double hit lymphoma) and start of therapy. Although the course of TLS would have required intensive care, the patient rejected such treatment for personal reasons and died soon after the discontinuation of therapy. The case emphasizes the life-saving relevance of early detection and appropriate treatment of TLS. It also demonstrates the importance of actively screening for TLS, primarily in patients with malignant diseases and high tumor load, even if they are not receiving cytotoxic therapy. |
| first_indexed | 2024-12-12T19:42:28Z |
| format | Article |
| id | doaj.art-ffb740a5804b483f8e27a0e058b4e944 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-12T19:42:28Z |
| publishDate | 2020-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-ffb740a5804b483f8e27a0e058b4e9442022-12-22T00:14:11ZengKarger PublishersCase Reports in Oncology1662-65752020-09-011331116112410.1159/000509643509643Spontaneous Tumor Lysis SyndromeWiebke WesemüllerChristian TavernaTumor lysis syndrome (TLS) is a hemato-oncological emergency characterized by metabolic and electrolyte imbalances which are associated with disintegrating tumor cells. The syndrome is frequently observed when starting cytotoxic treatment of hematological malignancies, while the incidence of spontaneous tumor lysis prior to the start of tumor therapy is rare. Here, we present a case of spontaneous TLS in a male patient who was referred with unspecific symptoms and suspected metastatic malignancy. He developed acute renal failure before the diagnosis of a high-grade B-cell lymphoma (double hit lymphoma) and start of therapy. Although the course of TLS would have required intensive care, the patient rejected such treatment for personal reasons and died soon after the discontinuation of therapy. The case emphasizes the life-saving relevance of early detection and appropriate treatment of TLS. It also demonstrates the importance of actively screening for TLS, primarily in patients with malignant diseases and high tumor load, even if they are not receiving cytotoxic therapy.https://www.karger.com/Article/FullText/509643acute renal failurehyperkalemiahyperuricemiaoncological emergencyspontaneous tumor lysis syndrome |
| spellingShingle | Wiebke Wesemüller Christian Taverna Spontaneous Tumor Lysis Syndrome Case Reports in Oncology acute renal failure hyperkalemia hyperuricemia oncological emergency spontaneous tumor lysis syndrome |
| title | Spontaneous Tumor Lysis Syndrome |
| title_full | Spontaneous Tumor Lysis Syndrome |
| title_fullStr | Spontaneous Tumor Lysis Syndrome |
| title_full_unstemmed | Spontaneous Tumor Lysis Syndrome |
| title_short | Spontaneous Tumor Lysis Syndrome |
| title_sort | spontaneous tumor lysis syndrome |
| topic | acute renal failure hyperkalemia hyperuricemia oncological emergency spontaneous tumor lysis syndrome |
| url | https://www.karger.com/Article/FullText/509643 |
| work_keys_str_mv | AT wiebkewesemuller spontaneoustumorlysissyndrome AT christiantaverna spontaneoustumorlysissyndrome |