The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma
Background: Cuproptosis has been recognized as a novel regulatory cell death, which has been confirmed to promote the occurrence and development of tumors. However, whether cuproptosis-related lncRNA has an impact on the prognosis of squamous cell carcinoma of the head and neck (HNSCC) is still uncl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.942785/full |
| _version_ | 1818477737843621888 |
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| author | Yao jun Li Hai yan Li Quan Zhang Sheng li Wei |
| author_facet | Yao jun Li Hai yan Li Quan Zhang Sheng li Wei |
| author_sort | Yao jun Li |
| collection | DOAJ |
| description | Background: Cuproptosis has been recognized as a novel regulatory cell death, which has been confirmed to promote the occurrence and development of tumors. However, whether cuproptosis-related lncRNA has an impact on the prognosis of squamous cell carcinoma of the head and neck (HNSCC) is still unclear.Methods: In total, 501 HNSCC tumor samples and 44 normal were downloaded from the TCGA database. Cuproptosis-related lncRNAs were obtained by co-expressed analysis. We got prognostic lncRNA that was associated with cuproptosis by using univariate Cox regression analysis and LASSO Cox regression. Then we constructed and validated the prognostic signature of HNSCC and analyzed the immune landscape of the signature.Results: The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). Consensus clustering was identified in molecular subtypes of HNSC. More high-risk samples concentrated in Cluster1, which had a higher Tumor Immune Dysfunction and Exclusion (TIDE) score and Single Nucleotide Polymorphisms (SNP) alternation than Cluster2.Conclusion: Our study elucidated the correlation between cuproptosis-related lncRNA with prognosis and immune landscape of HNSCC, which may provide references for further research on the exploration of the mechanism and functions of the prognosis for HNSCC. |
| first_indexed | 2024-12-10T09:40:52Z |
| format | Article |
| id | doaj.art-ffb7794e4a3043c489a66cb3d114e729 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T09:40:52Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ffb7794e4a3043c489a66cb3d114e7292022-12-22T01:54:00ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-07-011310.3389/fgene.2022.942785942785The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinomaYao jun Li0Hai yan Li1Quan Zhang2Sheng li Wei3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin Huanhu Hospital, Tianjin, ChinaTianjin Union Medical Center, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaBackground: Cuproptosis has been recognized as a novel regulatory cell death, which has been confirmed to promote the occurrence and development of tumors. However, whether cuproptosis-related lncRNA has an impact on the prognosis of squamous cell carcinoma of the head and neck (HNSCC) is still unclear.Methods: In total, 501 HNSCC tumor samples and 44 normal were downloaded from the TCGA database. Cuproptosis-related lncRNAs were obtained by co-expressed analysis. We got prognostic lncRNA that was associated with cuproptosis by using univariate Cox regression analysis and LASSO Cox regression. Then we constructed and validated the prognostic signature of HNSCC and analyzed the immune landscape of the signature.Results: The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). Consensus clustering was identified in molecular subtypes of HNSC. More high-risk samples concentrated in Cluster1, which had a higher Tumor Immune Dysfunction and Exclusion (TIDE) score and Single Nucleotide Polymorphisms (SNP) alternation than Cluster2.Conclusion: Our study elucidated the correlation between cuproptosis-related lncRNA with prognosis and immune landscape of HNSCC, which may provide references for further research on the exploration of the mechanism and functions of the prognosis for HNSCC.https://www.frontiersin.org/articles/10.3389/fgene.2022.942785/fullcuproptosislong non-coding RNAhead and neck squamous cell carcinomaprognostic signatureimmune landscape |
| spellingShingle | Yao jun Li Hai yan Li Quan Zhang Sheng li Wei The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma Frontiers in Genetics cuproptosis long non-coding RNA head and neck squamous cell carcinoma prognostic signature immune landscape |
| title | The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma |
| title_full | The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma |
| title_fullStr | The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma |
| title_full_unstemmed | The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma |
| title_short | The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma |
| title_sort | prognostic value and immune landscape of a cuproptosis related lncrna signature in head and neck squamous cell carcinoma |
| topic | cuproptosis long non-coding RNA head and neck squamous cell carcinoma prognostic signature immune landscape |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.942785/full |
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