Melatonin: a modulator in metabolic rewiring in T-cell malignancies
Melatonin, (N-acetyl-5-methoxytryptamine) an indoleamine exerts multifaced effects and regulates numerous cellular pathways and molecular targets associated with circadian rhythm, immune modulation, and seasonal reproduction including metabolic rewiring during T cell malignancy. T-cell malignancies...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1248339/full |
| _version_ | 1797362364918530048 |
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| author | Seema Rai Gunja Roy Younis Ahmad Hajam |
| author_facet | Seema Rai Gunja Roy Younis Ahmad Hajam |
| author_sort | Seema Rai |
| collection | DOAJ |
| description | Melatonin, (N-acetyl-5-methoxytryptamine) an indoleamine exerts multifaced effects and regulates numerous cellular pathways and molecular targets associated with circadian rhythm, immune modulation, and seasonal reproduction including metabolic rewiring during T cell malignancy. T-cell malignancies encompass a group of hematological cancers characterized by the uncontrolled growth and proliferation of malignant T-cells. These cancer cells exhibit a distinct metabolic adaptation, a hallmark of cancer in general, as they rewire their metabolic pathways to meet the heightened energy requirements and biosynthesis necessary for malignancies is the Warburg effect, characterized by a shift towards glycolysis, even when oxygen is available. In addition, T-cell malignancies cause metabolic shift by inhibiting the enzyme pyruvate Dehydrogenase Kinase (PDK) which in turn results in increased acetyl CoA enzyme production and cellular glycolytic activity. Further, melatonin plays a modulatory role in the expression of essential transporters (Glut1, Glut2) responsible for nutrient uptake and metabolic rewiring, such as glucose and amino acid transporters in T-cells. This modulation significantly impacts the metabolic profile of T-cells, consequently affecting their differentiation. Furthermore, melatonin has been found to regulate the expression of critical signaling molecules involved in T-cell activations, such as CD38, and CD69. These molecules are integral to T-cell adhesion, signaling, and activation. This review aims to provide insights into the mechanism of melatonin’s anticancer properties concerning metabolic rewiring during T-cell malignancy. The present review encompasses the involvement of oncogenic factors, the tumor microenvironment and metabolic alteration, hallmarks, metabolic reprogramming, and the anti-oncogenic/oncostatic impact of melatonin on various cancer cells. |
| first_indexed | 2024-03-08T16:07:00Z |
| format | Article |
| id | doaj.art-ffb9bbed40274d57b787152cedc2e3f7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T16:07:00Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ffb9bbed40274d57b787152cedc2e3f72024-01-08T05:45:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.12483391248339Melatonin: a modulator in metabolic rewiring in T-cell malignanciesSeema Rai0Gunja Roy1Younis Ahmad Hajam2Department of Zoology Guru Ghasidas Vishwavidyalaya, Bilaspur, IndiaDepartment of Zoology Guru Ghasidas Vishwavidyalaya, Bilaspur, IndiaDepartment of Life Sciences and Allied Health Sciences, Sant Bhag Singh University, Jalandhar, IndiaMelatonin, (N-acetyl-5-methoxytryptamine) an indoleamine exerts multifaced effects and regulates numerous cellular pathways and molecular targets associated with circadian rhythm, immune modulation, and seasonal reproduction including metabolic rewiring during T cell malignancy. T-cell malignancies encompass a group of hematological cancers characterized by the uncontrolled growth and proliferation of malignant T-cells. These cancer cells exhibit a distinct metabolic adaptation, a hallmark of cancer in general, as they rewire their metabolic pathways to meet the heightened energy requirements and biosynthesis necessary for malignancies is the Warburg effect, characterized by a shift towards glycolysis, even when oxygen is available. In addition, T-cell malignancies cause metabolic shift by inhibiting the enzyme pyruvate Dehydrogenase Kinase (PDK) which in turn results in increased acetyl CoA enzyme production and cellular glycolytic activity. Further, melatonin plays a modulatory role in the expression of essential transporters (Glut1, Glut2) responsible for nutrient uptake and metabolic rewiring, such as glucose and amino acid transporters in T-cells. This modulation significantly impacts the metabolic profile of T-cells, consequently affecting their differentiation. Furthermore, melatonin has been found to regulate the expression of critical signaling molecules involved in T-cell activations, such as CD38, and CD69. These molecules are integral to T-cell adhesion, signaling, and activation. This review aims to provide insights into the mechanism of melatonin’s anticancer properties concerning metabolic rewiring during T-cell malignancy. The present review encompasses the involvement of oncogenic factors, the tumor microenvironment and metabolic alteration, hallmarks, metabolic reprogramming, and the anti-oncogenic/oncostatic impact of melatonin on various cancer cells.https://www.frontiersin.org/articles/10.3389/fonc.2023.1248339/fullT-cell malignancymelatoninmetabolic rewiringtumor microenvironmentT-cell exhaustioncancer |
| spellingShingle | Seema Rai Gunja Roy Younis Ahmad Hajam Melatonin: a modulator in metabolic rewiring in T-cell malignancies Frontiers in Oncology T-cell malignancy melatonin metabolic rewiring tumor microenvironment T-cell exhaustion cancer |
| title | Melatonin: a modulator in metabolic rewiring in T-cell malignancies |
| title_full | Melatonin: a modulator in metabolic rewiring in T-cell malignancies |
| title_fullStr | Melatonin: a modulator in metabolic rewiring in T-cell malignancies |
| title_full_unstemmed | Melatonin: a modulator in metabolic rewiring in T-cell malignancies |
| title_short | Melatonin: a modulator in metabolic rewiring in T-cell malignancies |
| title_sort | melatonin a modulator in metabolic rewiring in t cell malignancies |
| topic | T-cell malignancy melatonin metabolic rewiring tumor microenvironment T-cell exhaustion cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1248339/full |
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