Patient-derived xenografts: a promising resource for preclinical cancer research
Patient-derived xenograft tumors retain molecular and histopathological features of the originating tumor and are useful preclinical tools for drug discovery and assessment. We recently reported that ‘rapid’ engraftment of head and neck squamous cell carcinoma samples is highly prognostic and correl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1558684 |
| _version_ | 1797677186682978304 |
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| author | Christina Karamboulas Laurie Ailles |
| author_facet | Christina Karamboulas Laurie Ailles |
| author_sort | Christina Karamboulas |
| collection | DOAJ |
| description | Patient-derived xenograft tumors retain molecular and histopathological features of the originating tumor and are useful preclinical tools for drug discovery and assessment. We recently reported that ‘rapid’ engraftment of head and neck squamous cell carcinoma samples is highly prognostic and correlates with deregulation of the G1/S checkpoint. Tumors with genetic alterations in cyclinD1 (CCND1) and/or cyclin-dependent kinase inhibitor 2A (CDKN2A) are more likely to respond to abemaciclib. |
| first_indexed | 2024-03-11T22:41:24Z |
| format | Article |
| id | doaj.art-ffbd4c4190574e68811e2e719714d9db |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:24Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ffbd4c4190574e68811e2e719714d9db2023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-01-016110.1080/23723556.2018.15586841558684Patient-derived xenografts: a promising resource for preclinical cancer researchChristina Karamboulas0Laurie Ailles1University Health NetworkUniversity Health NetworkPatient-derived xenograft tumors retain molecular and histopathological features of the originating tumor and are useful preclinical tools for drug discovery and assessment. We recently reported that ‘rapid’ engraftment of head and neck squamous cell carcinoma samples is highly prognostic and correlates with deregulation of the G1/S checkpoint. Tumors with genetic alterations in cyclinD1 (CCND1) and/or cyclin-dependent kinase inhibitor 2A (CDKN2A) are more likely to respond to abemaciclib.http://dx.doi.org/10.1080/23723556.2018.1558684patient-derived xenograftshead and neck squamous cell carcinomaengraftmentpreclinical toolbiomarker discoveryabemaciclib |
| spellingShingle | Christina Karamboulas Laurie Ailles Patient-derived xenografts: a promising resource for preclinical cancer research Molecular & Cellular Oncology patient-derived xenografts head and neck squamous cell carcinoma engraftment preclinical tool biomarker discovery abemaciclib |
| title | Patient-derived xenografts: a promising resource for preclinical cancer research |
| title_full | Patient-derived xenografts: a promising resource for preclinical cancer research |
| title_fullStr | Patient-derived xenografts: a promising resource for preclinical cancer research |
| title_full_unstemmed | Patient-derived xenografts: a promising resource for preclinical cancer research |
| title_short | Patient-derived xenografts: a promising resource for preclinical cancer research |
| title_sort | patient derived xenografts a promising resource for preclinical cancer research |
| topic | patient-derived xenografts head and neck squamous cell carcinoma engraftment preclinical tool biomarker discovery abemaciclib |
| url | http://dx.doi.org/10.1080/23723556.2018.1558684 |
| work_keys_str_mv | AT christinakaramboulas patientderivedxenograftsapromisingresourceforpreclinicalcancerresearch AT laurieailles patientderivedxenograftsapromisingresourceforpreclinicalcancerresearch |