Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss
<p>Abstract</p> <p>Background</p> <p>HER2/<it>neu </it>is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-02-01
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| Series: | Nutrition & Metabolism |
| Online Access: | http://www.nutritionandmetabolism.com/content/7/1/14 |
| _version_ | 1818520507167801344 |
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| author | Moreno-Navarrete José Frühbeck Gema Menendez Javier A Fernández-Real José Vazquez-Martín Alejandro Ricart Wifredo |
| author_facet | Moreno-Navarrete José Frühbeck Gema Menendez Javier A Fernández-Real José Vazquez-Martín Alejandro Ricart Wifredo |
| author_sort | Moreno-Navarrete José |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>HER2/<it>neu </it>is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects.</p> <p>Methods</p> <p>Insulin sensitivity (minimal model) and serum HER-2 concentrations were evaluated in a cross sectional study in men (cohort 1, n = 167) and longitudinally after weight loss in obese subjects (cohort 2, n = 30).</p> <p>Results</p> <p>Serum HER-2 concentrations were positively associated with BMI and waist circumference (both r = 0.18, p = 0.02), post-load glucose (r = 0.28, p = 0.001) and fasting triglycerides (r = 0.26, p = 0.001); and negatively associated with insulin sensitivity (r = -0.29, p = 0.002, n = 109). Subjects with type 2 diabetes showed significantly increased soluble serum HER-2 concentrations. In different multivariate regression models, fasting triglycerides emerged as the factor that independently contributed to 10-11% of serum HER-2 variance.</p> <p>Serum HER-2 concentrations correlated significantly with fasting triglycerides and insulin sensitivity index in subjects from cohort 2. Weight loss led to a significant decrease of serum HER-2 concentrations. The change in serum HER-2 concentrations were significantly associated with the change in percent body fat and fasting triglycerides in young (below the median age of the cohort) subjects.</p> <p>Conclusions</p> <p>Serum HER-2 concentrations might be implicated in the pathophysiology of insulin resistance and associated comorbidities.</p> |
| first_indexed | 2024-12-11T01:38:27Z |
| format | Article |
| id | doaj.art-ffbee68098f44e4580e43139a4df5909 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-11T01:38:27Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-ffbee68098f44e4580e43139a4df59092022-12-22T01:25:07ZengBMCNutrition & Metabolism1743-70752010-02-01711410.1186/1743-7075-7-14Serum HER-2 concentration is associated with insulin resistance and decreases after weight lossMoreno-Navarrete JoséFrühbeck GemaMenendez Javier AFernández-Real JoséVazquez-Martín AlejandroRicart Wifredo<p>Abstract</p> <p>Background</p> <p>HER2/<it>neu </it>is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects.</p> <p>Methods</p> <p>Insulin sensitivity (minimal model) and serum HER-2 concentrations were evaluated in a cross sectional study in men (cohort 1, n = 167) and longitudinally after weight loss in obese subjects (cohort 2, n = 30).</p> <p>Results</p> <p>Serum HER-2 concentrations were positively associated with BMI and waist circumference (both r = 0.18, p = 0.02), post-load glucose (r = 0.28, p = 0.001) and fasting triglycerides (r = 0.26, p = 0.001); and negatively associated with insulin sensitivity (r = -0.29, p = 0.002, n = 109). Subjects with type 2 diabetes showed significantly increased soluble serum HER-2 concentrations. In different multivariate regression models, fasting triglycerides emerged as the factor that independently contributed to 10-11% of serum HER-2 variance.</p> <p>Serum HER-2 concentrations correlated significantly with fasting triglycerides and insulin sensitivity index in subjects from cohort 2. Weight loss led to a significant decrease of serum HER-2 concentrations. The change in serum HER-2 concentrations were significantly associated with the change in percent body fat and fasting triglycerides in young (below the median age of the cohort) subjects.</p> <p>Conclusions</p> <p>Serum HER-2 concentrations might be implicated in the pathophysiology of insulin resistance and associated comorbidities.</p>http://www.nutritionandmetabolism.com/content/7/1/14 |
| spellingShingle | Moreno-Navarrete José Frühbeck Gema Menendez Javier A Fernández-Real José Vazquez-Martín Alejandro Ricart Wifredo Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss Nutrition & Metabolism |
| title | Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss |
| title_full | Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss |
| title_fullStr | Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss |
| title_full_unstemmed | Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss |
| title_short | Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss |
| title_sort | serum her 2 concentration is associated with insulin resistance and decreases after weight loss |
| url | http://www.nutritionandmetabolism.com/content/7/1/14 |
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