Cancer chemoprevention through Frizzled receptors and EMT
Abstract Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing. FZDs are often associated with the process of epithelial to mesenchymal transition (EMT) through β-catenin, bu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-09-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-021-00429-2 |
| _version_ | 1819023652859936768 |
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| author | K. Sompel A. Elango A. J. Smith M. A. Tennis |
| author_facet | K. Sompel A. Elango A. J. Smith M. A. Tennis |
| author_sort | K. Sompel |
| collection | DOAJ |
| description | Abstract Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing. FZDs are often associated with the process of epithelial to mesenchymal transition (EMT) through β-catenin, but some also influence EMT through non-canonical pathways. With ten different FZDs, there is a wide range of activity from oncogenic to tumor suppressive depending on the tissue context. Alterations in FZD signaling can occur during development of premalignant lesions, supporting their potential as targets of chemoprevention agents. Agonizing or antagonizing FZD activity may affect EMT, which is a key process in lesion progression often targeted by chemoprevention agents. Recent studies identified a specific FZD as important for activity of an EMT inhibiting chemopreventive agent and other studies have highlighted the previously unrecognized potential for targeting small molecules to FZD receptors. This work demonstrates the value of investigating FZDs in chemoprevention and here we provide a review of FZDs in cancer EMT and their potential as chemoprevention targets. |
| first_indexed | 2024-12-21T04:42:18Z |
| format | Article |
| id | doaj.art-ffbfd3ad847b41e99bfe973597f0a549 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-12-21T04:42:18Z |
| publishDate | 2021-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-ffbfd3ad847b41e99bfe973597f0a5492022-12-21T19:15:40ZengSpringerDiscover Oncology2730-60112021-09-0112111510.1007/s12672-021-00429-2Cancer chemoprevention through Frizzled receptors and EMTK. Sompel0A. Elango1A. J. Smith2M. A. Tennis3Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical CampusDivision of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical CampusDivision of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical CampusDivision of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical CampusAbstract Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing. FZDs are often associated with the process of epithelial to mesenchymal transition (EMT) through β-catenin, but some also influence EMT through non-canonical pathways. With ten different FZDs, there is a wide range of activity from oncogenic to tumor suppressive depending on the tissue context. Alterations in FZD signaling can occur during development of premalignant lesions, supporting their potential as targets of chemoprevention agents. Agonizing or antagonizing FZD activity may affect EMT, which is a key process in lesion progression often targeted by chemoprevention agents. Recent studies identified a specific FZD as important for activity of an EMT inhibiting chemopreventive agent and other studies have highlighted the previously unrecognized potential for targeting small molecules to FZD receptors. This work demonstrates the value of investigating FZDs in chemoprevention and here we provide a review of FZDs in cancer EMT and their potential as chemoprevention targets.https://doi.org/10.1007/s12672-021-00429-2FrizzledChemopreventionCancerEpithelial to mesenchymal transition |
| spellingShingle | K. Sompel A. Elango A. J. Smith M. A. Tennis Cancer chemoprevention through Frizzled receptors and EMT Discover Oncology Frizzled Chemoprevention Cancer Epithelial to mesenchymal transition |
| title | Cancer chemoprevention through Frizzled receptors and EMT |
| title_full | Cancer chemoprevention through Frizzled receptors and EMT |
| title_fullStr | Cancer chemoprevention through Frizzled receptors and EMT |
| title_full_unstemmed | Cancer chemoprevention through Frizzled receptors and EMT |
| title_short | Cancer chemoprevention through Frizzled receptors and EMT |
| title_sort | cancer chemoprevention through frizzled receptors and emt |
| topic | Frizzled Chemoprevention Cancer Epithelial to mesenchymal transition |
| url | https://doi.org/10.1007/s12672-021-00429-2 |
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