FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced lipotoxicity

FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced lipotoxicity

Abstract Background Excessive dietary fat intake induces lipid deposition and contributes to the progress of nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are still unclear. Methods Yellow catfish were given two experimental diets with dietary lipid levels of 11.3 and...

Full description

Bibliographic Details
Main Authors: Kun Wu, Tao Zhao, Christer Hogstrand, Yi-Chuang Xu, Shi-Cheng Ling, Guang-Hui Chen, Zhi Luo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell Communication and Signaling
Subjects:
Lipid metabolism
RNA-seq transcriptome
Autophagy
FXR
Lipotoxicity
Online Access:http://link.springer.com/article/10.1186/s12964-020-0525-1

Internet

http://link.springer.com/article/10.1186/s12964-020-0525-1

Similar Items