pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior
The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/12/9/1974 |
| _version_ | 1797555089625317376 |
|---|---|
| author | Juan Carlos Quintanilla de Stéfano Vanessa Abundis-Correa Sergio Daniel Herrera-Flores Alejandro J. Alvarez |
| author_facet | Juan Carlos Quintanilla de Stéfano Vanessa Abundis-Correa Sergio Daniel Herrera-Flores Alejandro J. Alvarez |
| author_sort | Juan Carlos Quintanilla de Stéfano |
| collection | DOAJ |
| description | The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications. |
| first_indexed | 2024-03-10T16:42:30Z |
| format | Article |
| id | doaj.art-ffc206e92bea485e8ce702f61c6448bd |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T16:42:30Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ffc206e92bea485e8ce702f61c6448bd2023-11-20T11:58:06ZengMDPI AGPolymers2073-43602020-08-01129197410.3390/polym12091974pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release BehaviorJuan Carlos Quintanilla de Stéfano0Vanessa Abundis-Correa1Sergio Daniel Herrera-Flores2Alejandro J. Alvarez3School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoThe drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.https://www.mdpi.com/2073-4360/12/9/1974hydrogelcontrolled drug releasestarch copolymerscaffeineswelling behavior |
| spellingShingle | Juan Carlos Quintanilla de Stéfano Vanessa Abundis-Correa Sergio Daniel Herrera-Flores Alejandro J. Alvarez pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior Polymers hydrogel controlled drug release starch copolymers caffeine swelling behavior |
| title | pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior |
| title_full | pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior |
| title_fullStr | pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior |
| title_full_unstemmed | pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior |
| title_short | pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior |
| title_sort | ph sensitive starch based hydrogels synthesis and effect of molecular components on drug release behavior |
| topic | hydrogel controlled drug release starch copolymers caffeine swelling behavior |
| url | https://www.mdpi.com/2073-4360/12/9/1974 |
| work_keys_str_mv | AT juancarlosquintanilladestefano phsensitivestarchbasedhydrogelssynthesisandeffectofmolecularcomponentsondrugreleasebehavior AT vanessaabundiscorrea phsensitivestarchbasedhydrogelssynthesisandeffectofmolecularcomponentsondrugreleasebehavior AT sergiodanielherreraflores phsensitivestarchbasedhydrogelssynthesisandeffectofmolecularcomponentsondrugreleasebehavior AT alejandrojalvarez phsensitivestarchbasedhydrogelssynthesisandeffectofmolecularcomponentsondrugreleasebehavior |