Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review
Introduction: Acute Generalized Exanthematous Pustulosis (AGEP) is a cutaneous reaction that may appear after using certain medications, such as cephalexin. This disease is characterized by non-follicular sterile pustules, erythematous, urticaria, fever over , and leukocytosis. Cephalexin belongs to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2021-07-01
|
| Series: | Journal of Pediatrics Review |
| Subjects: | |
| Online Access: | http://jpr.mazums.ac.ir/article-1-345-en.html |
| _version_ | 1818725304707842048 |
|---|---|
| author | Shirin Sheibani Mahdie Sadat Mousavi Hamed Jafarpour Javad Ghaffari Abbas Dabbaghzadeh Salar Behzadnia |
| author_facet | Shirin Sheibani Mahdie Sadat Mousavi Hamed Jafarpour Javad Ghaffari Abbas Dabbaghzadeh Salar Behzadnia |
| author_sort | Shirin Sheibani |
| collection | DOAJ |
| description | Introduction: Acute Generalized Exanthematous Pustulosis (AGEP) is a cutaneous reaction that may appear after using certain medications, such as cephalexin. This disease is characterized by non-follicular sterile pustules, erythematous, urticaria, fever over , and leukocytosis. Cephalexin belongs to the family of β-lactam antibiotics, which are widely used to treat infections. However, cephalexin skin sensitivities have been reported rarely. Herein, in this case, we aimed to report a patient presented with AGEP due to cephalexin usage.
Case Presentation: A 12-year-old boy presented with warm skin lesions that gradually appeared on the limbs, trunk, face, and neck after using cephalexin powder on his left leg injury. Because of his symptoms, acetaminophen, fexofenadine hydrochloride, loxoprofen sodium, and ointment, including difluprednate and hydrocortisone, were prescribed. Over time, the patient’s fever subsided, and 8 days later, the symptoms of AGEP, including urticaria, erythematous, and pustules in the neck and trunk, disappeared.
Conclusions: Cephalexin is one of the antibiotics that doctors and patients consider when there is a possibility of infection. AGEP is a rare but severe reaction that can manifest as skin rashes in any age and sex following the use of cephalexin, so the patient should be careful when using this antibiotic. |
| first_indexed | 2024-12-17T21:40:11Z |
| format | Article |
| id | doaj.art-ffc228a5b49e45cbb9eb89595890457f |
| institution | Directory Open Access Journal |
| issn | 2322-4398 2322-4401 |
| language | English |
| last_indexed | 2024-12-17T21:40:11Z |
| publishDate | 2021-07-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Pediatrics Review |
| spelling | doaj.art-ffc228a5b49e45cbb9eb89595890457f2022-12-21T21:31:39ZengMazandaran University of Medical SciencesJournal of Pediatrics Review2322-43982322-44012021-07-0193263268Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature ReviewShirin Sheibani0Mahdie Sadat Mousavi1Hamed Jafarpour2Javad Ghaffari3Abbas Dabbaghzadeh 4Salar Behzadnia5Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pediatrics, School of Medicine, Pediatric Infectious Diseases Research Center, Bu-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Introduction: Acute Generalized Exanthematous Pustulosis (AGEP) is a cutaneous reaction that may appear after using certain medications, such as cephalexin. This disease is characterized by non-follicular sterile pustules, erythematous, urticaria, fever over , and leukocytosis. Cephalexin belongs to the family of β-lactam antibiotics, which are widely used to treat infections. However, cephalexin skin sensitivities have been reported rarely. Herein, in this case, we aimed to report a patient presented with AGEP due to cephalexin usage. Case Presentation: A 12-year-old boy presented with warm skin lesions that gradually appeared on the limbs, trunk, face, and neck after using cephalexin powder on his left leg injury. Because of his symptoms, acetaminophen, fexofenadine hydrochloride, loxoprofen sodium, and ointment, including difluprednate and hydrocortisone, were prescribed. Over time, the patient’s fever subsided, and 8 days later, the symptoms of AGEP, including urticaria, erythematous, and pustules in the neck and trunk, disappeared. Conclusions: Cephalexin is one of the antibiotics that doctors and patients consider when there is a possibility of infection. AGEP is a rare but severe reaction that can manifest as skin rashes in any age and sex following the use of cephalexin, so the patient should be careful when using this antibiotic.http://jpr.mazums.ac.ir/article-1-345-en.htmlacute generalized exanthematous pustulosiscephalexinadverse drug reaction |
| spellingShingle | Shirin Sheibani Mahdie Sadat Mousavi Hamed Jafarpour Javad Ghaffari Abbas Dabbaghzadeh Salar Behzadnia Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review Journal of Pediatrics Review acute generalized exanthematous pustulosis cephalexin adverse drug reaction |
| title | Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review |
| title_full | Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review |
| title_fullStr | Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review |
| title_full_unstemmed | Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review |
| title_short | Acute Generalized Exanthematous Pustulosis Due to Cephalexin: A Case Report and Literature Review |
| title_sort | acute generalized exanthematous pustulosis due to cephalexin a case report and literature review |
| topic | acute generalized exanthematous pustulosis cephalexin adverse drug reaction |
| url | http://jpr.mazums.ac.ir/article-1-345-en.html |
| work_keys_str_mv | AT shirinsheibani acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview AT mahdiesadatmousavi acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview AT hamedjafarpour acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview AT javadghaffari acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview AT abbasdabbaghzadeh acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview AT salarbehzadnia acutegeneralizedexanthematouspustulosisduetocephalexinacasereportandliteraturereview |