Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway
Abstract Triple-negative breast cancer (TNBC) is a pathological subtype of breast cancer (BC) with high malignancy, strong invasiveness and poor prognosis. Long non-coding RNA (LncRNA) plays an important role during tumorigenesis. We identified that Linc00707 was upregulated in TNBC tissues by TCGA...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-01906-7 |
| _version_ | 1797259542196649984 |
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| author | Hongli Li Qinghua Liu Yaqiong Hu Chonggao Yin Yunxiang Zhang Peng Gao |
| author_facet | Hongli Li Qinghua Liu Yaqiong Hu Chonggao Yin Yunxiang Zhang Peng Gao |
| author_sort | Hongli Li |
| collection | DOAJ |
| description | Abstract Triple-negative breast cancer (TNBC) is a pathological subtype of breast cancer (BC) with high malignancy, strong invasiveness and poor prognosis. Long non-coding RNA (LncRNA) plays an important role during tumorigenesis. We identified that Linc00707 was upregulated in TNBC tissues by TCGA database and RT-qPCR assay, compared with normal breast tissues and other subtypes of BC. Linc00707 promoted TNBC cells proliferation, migration and invasion. Furthermore, we found that knockdown of Linc00707 influenced autophagy via PI3K/AKT/mTOR signaling pathway in TNBC cells. Linc00707 affected the progress of TNBC cells through affecting autophagy. Further mechanistic experiments confirmed that Linc00707 could competitively bind with miR-423-5p to up-regulate MARCH2 expression, ultimately promoting TNBC progression and autophagy through PI3K/AKT/mTOR pathway. In conclusion, we demonstrate that Linc00707 is a key molecule in tumor progression and may be an effective target for patients with TNBC. |
| first_indexed | 2024-04-24T23:11:05Z |
| format | Article |
| id | doaj.art-ffc3449ffd1348d697f297c8aff4deff |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-24T23:11:05Z |
| publishDate | 2024-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-ffc3449ffd1348d697f297c8aff4deff2024-03-17T12:14:41ZengNature Publishing GroupCell Death Discovery2058-77162024-03-0110111410.1038/s41420-024-01906-7Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathwayHongli Li0Qinghua Liu1Yaqiong Hu2Chonggao Yin3Yunxiang Zhang4Peng Gao5Department of Pathology, Qi Lu Hospital and School of Basic Medical Sciences, Shandong UniversityMedicine Research Center, Shandong Second Medical UniversityMedicine Research Center, Shandong Second Medical UniversityCollege of Nursing, Shandong Second Medical UniversityDepartment of Pathology, Qi Lu Hospital and School of Basic Medical Sciences, Shandong UniversityDepartment of Pathology, Qi Lu Hospital and School of Basic Medical Sciences, Shandong UniversityAbstract Triple-negative breast cancer (TNBC) is a pathological subtype of breast cancer (BC) with high malignancy, strong invasiveness and poor prognosis. Long non-coding RNA (LncRNA) plays an important role during tumorigenesis. We identified that Linc00707 was upregulated in TNBC tissues by TCGA database and RT-qPCR assay, compared with normal breast tissues and other subtypes of BC. Linc00707 promoted TNBC cells proliferation, migration and invasion. Furthermore, we found that knockdown of Linc00707 influenced autophagy via PI3K/AKT/mTOR signaling pathway in TNBC cells. Linc00707 affected the progress of TNBC cells through affecting autophagy. Further mechanistic experiments confirmed that Linc00707 could competitively bind with miR-423-5p to up-regulate MARCH2 expression, ultimately promoting TNBC progression and autophagy through PI3K/AKT/mTOR pathway. In conclusion, we demonstrate that Linc00707 is a key molecule in tumor progression and may be an effective target for patients with TNBC.https://doi.org/10.1038/s41420-024-01906-7 |
| spellingShingle | Hongli Li Qinghua Liu Yaqiong Hu Chonggao Yin Yunxiang Zhang Peng Gao Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway Cell Death Discovery |
| title | Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway |
| title_full | Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway |
| title_fullStr | Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway |
| title_full_unstemmed | Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway |
| title_short | Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway |
| title_sort | linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of pi3k akt mtor pathway |
| url | https://doi.org/10.1038/s41420-024-01906-7 |
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