Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea
Obstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cognitive impairment is a signifi- cant and common OSA complication often described in such patients. The most commonly utilized methods in clinical OSA treatment are oral appliance...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1222626/full |
| _version_ | 1797693046901440512 |
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| author | Daqiang He Jian Chen Xiaoxue Du Linhao Xu Linhao Xu |
| author_facet | Daqiang He Jian Chen Xiaoxue Du Linhao Xu Linhao Xu |
| author_sort | Daqiang He |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cognitive impairment is a signifi- cant and common OSA complication often described in such patients. The most commonly utilized methods in clinical OSA treatment are oral appliances and continuous positive airway pressure (CPAP). However, the current therapeutic methods for improving cognitive function could not achieve the expected efficacy in same patients. Therefore, further understanding the molecular mechanism behind cognitive dysfunction in OSA disease will provide new treatment methods and targets. This review briefly summarized the clinical manifestations of cognitive impairment in OSA disease. Moreover, the pathophysiological molecular mechanism of OSA was outlined. Our study concluded that both SF and IH could induce cognitive impairment by multiple signaling pathways, such as oxidative stress activation, inflammation, and apoptosis. However, there is a lack of effective drug therapy for cognitive impairment in OSA. Finally, the therapeutic potential of some novel compounds and herbal medicine was evaluated on attenuating cognitive impairment based on certain preclinical studies. |
| first_indexed | 2024-03-12T02:37:55Z |
| format | Article |
| id | doaj.art-ffc485c6a52544c98011aea54794600a |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-12T02:37:55Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-ffc485c6a52544c98011aea54794600a2023-09-04T13:37:27ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-09-011710.3389/fncel.2023.12226261222626Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apneaDaqiang He0Jian Chen1Xiaoxue Du2Linhao Xu3Linhao Xu4Department of Laboratory Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Translational Medicine Research Center, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Translational Medicine Research Center, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Cardiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaObstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cognitive impairment is a signifi- cant and common OSA complication often described in such patients. The most commonly utilized methods in clinical OSA treatment are oral appliances and continuous positive airway pressure (CPAP). However, the current therapeutic methods for improving cognitive function could not achieve the expected efficacy in same patients. Therefore, further understanding the molecular mechanism behind cognitive dysfunction in OSA disease will provide new treatment methods and targets. This review briefly summarized the clinical manifestations of cognitive impairment in OSA disease. Moreover, the pathophysiological molecular mechanism of OSA was outlined. Our study concluded that both SF and IH could induce cognitive impairment by multiple signaling pathways, such as oxidative stress activation, inflammation, and apoptosis. However, there is a lack of effective drug therapy for cognitive impairment in OSA. Finally, the therapeutic potential of some novel compounds and herbal medicine was evaluated on attenuating cognitive impairment based on certain preclinical studies.https://www.frontiersin.org/articles/10.3389/fncel.2023.1222626/fullobstructive sleep apneaintermittent hypoxiasleep fragmentationcognitive impairmentdrug therapy |
| spellingShingle | Daqiang He Jian Chen Xiaoxue Du Linhao Xu Linhao Xu Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea Frontiers in Cellular Neuroscience obstructive sleep apnea intermittent hypoxia sleep fragmentation cognitive impairment drug therapy |
| title | Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea |
| title_full | Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea |
| title_fullStr | Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea |
| title_full_unstemmed | Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea |
| title_short | Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea |
| title_sort | summary of drug therapy to treat cognitive impairment induced obstructive sleep apnea |
| topic | obstructive sleep apnea intermittent hypoxia sleep fragmentation cognitive impairment drug therapy |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1222626/full |
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