Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina.
The Major Histocompatibility Complex (MHC) class I is a highly variable gene family that encodes cell-surface receptors vital for recognition of intracellular pathogens and initiation of immune responses. The MHC class I has yet to be characterised in bufonid toads (Order: Anura; Suborder: Neobatrac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4122387?pdf=render |
| _version_ | 1819043472055730176 |
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| author | Mette Lillie Richard Shine Katherine Belov |
| author_facet | Mette Lillie Richard Shine Katherine Belov |
| author_sort | Mette Lillie |
| collection | DOAJ |
| description | The Major Histocompatibility Complex (MHC) class I is a highly variable gene family that encodes cell-surface receptors vital for recognition of intracellular pathogens and initiation of immune responses. The MHC class I has yet to be characterised in bufonid toads (Order: Anura; Suborder: Neobatrachia; Family: Bufonidae), a large and diverse family of anurans. Here we describe the characterisation of a classical MHC class I gene in the Australian cane toad, Rhinella marina. From 25 individuals sampled from the Australian population, we found only 3 alleles at this classical class I locus. We also found large number of class I alpha 1 alleles, implying an expansion of class I loci in this species. The low classical class I genetic diversity is likely the result of repeated bottleneck events, which arose as a result of the cane toad's complex history of introductions as a biocontrol agent and its subsequent invasion across Australia. |
| first_indexed | 2024-12-21T09:57:19Z |
| format | Article |
| id | doaj.art-ffc68f227a574376a0c3d8e28834bd2d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T09:57:19Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ffc68f227a574376a0c3d8e28834bd2d2022-12-21T19:08:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10282410.1371/journal.pone.0102824Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina.Mette LillieRichard ShineKatherine BelovThe Major Histocompatibility Complex (MHC) class I is a highly variable gene family that encodes cell-surface receptors vital for recognition of intracellular pathogens and initiation of immune responses. The MHC class I has yet to be characterised in bufonid toads (Order: Anura; Suborder: Neobatrachia; Family: Bufonidae), a large and diverse family of anurans. Here we describe the characterisation of a classical MHC class I gene in the Australian cane toad, Rhinella marina. From 25 individuals sampled from the Australian population, we found only 3 alleles at this classical class I locus. We also found large number of class I alpha 1 alleles, implying an expansion of class I loci in this species. The low classical class I genetic diversity is likely the result of repeated bottleneck events, which arose as a result of the cane toad's complex history of introductions as a biocontrol agent and its subsequent invasion across Australia.http://europepmc.org/articles/PMC4122387?pdf=render |
| spellingShingle | Mette Lillie Richard Shine Katherine Belov Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. PLoS ONE |
| title | Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. |
| title_full | Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. |
| title_fullStr | Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. |
| title_full_unstemmed | Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. |
| title_short | Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. |
| title_sort | characterisation of major histocompatibility complex class i in the australian cane toad rhinella marina |
| url | http://europepmc.org/articles/PMC4122387?pdf=render |
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