OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and en...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/415 |
| _version_ | 1826569828684529664 |
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| author | A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin |
| author_facet | A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin |
| author_sort | A. A. Boyko |
| collection | DOAJ |
| description | The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device. |
| first_indexed | 2024-04-10T01:40:51Z |
| format | Article |
| id | doaj.art-ffc7627ff3334d0bb9869712be1eed8e |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2025-03-14T11:45:32Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-ffc7627ff3334d0bb9869712be1eed8e2025-03-02T09:53:19ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102108114415OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTIONA. A. Boyko0S. V. Mordanov1T. G. Khonina2O. N. Chupahin3I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesChemical Engineering Institute of the Ural Federal University, Department of «Machinery and equipment of chemical plants»I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesI.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesThe process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.https://www.pharmjournal.ru/jour/article/view/415transesterification of silanessilicon derivatives of polyolscatalysiscomputational hydrodynamics |
| spellingShingle | A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION Разработка и регистрация лекарственных средств transesterification of silanes silicon derivatives of polyols catalysis computational hydrodynamics |
| title | OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION |
| title_full | OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION |
| title_fullStr | OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION |
| title_full_unstemmed | OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION |
| title_short | OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION |
| title_sort | optimization of experimental industrial technology of silicon containing derivatives of polyol substances production |
| topic | transesterification of silanes silicon derivatives of polyols catalysis computational hydrodynamics |
| url | https://www.pharmjournal.ru/jour/article/view/415 |
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