Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections
Procalcitonin (PCT) was established as a biomarker to discriminate bacterial infections from other proinflammatory conditions. Our objective was to determine whether PCT is effective in differentiating infection from antineutrophil-cytoplasmic-antibody (ANCA)-associated vasculitides (AAV) flare. In...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5557 |
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| author | Xavier Poirot-Seynaeve Perrine Smets Bruno Pereira Louis Olagne Julien Stievenart Vincent Sapin Olivier Aumaitre Marc Andre Ludovic Trefond |
| author_facet | Xavier Poirot-Seynaeve Perrine Smets Bruno Pereira Louis Olagne Julien Stievenart Vincent Sapin Olivier Aumaitre Marc Andre Ludovic Trefond |
| author_sort | Xavier Poirot-Seynaeve |
| collection | DOAJ |
| description | Procalcitonin (PCT) was established as a biomarker to discriminate bacterial infections from other proinflammatory conditions. Our objective was to determine whether PCT is effective in differentiating infection from antineutrophil-cytoplasmic-antibody (ANCA)-associated vasculitides (AAV) flare. In this retrospective, case-control study, PCT and other inflammatory biomarkers of patients with AAV relapse (relapsing group) were compared to infected AAV patients (infected group). In our population of 74 patients with AAV, PCT was significantly higher in the infected group than in the relapsing group (0.2 µg/L [0.08; 0.935] vs. 0.09 µg/L [0.05; 0.2], <i>p</i> < 0.001). Sensitivity and specificity were 53.4% and 73.6%, respectively, for an ideal threshold of 0.2 µg/L. C-reactive protein (CRP) was significantly higher in cases of infection than in relapse (64.7 mg/L [25; 131] vs. 31.5 mg/L, [10.6; 120], <i>p</i> = 0.001). Sensitivity and specificity for infections were 94.2% and 11.3%, respectively. Fibrinogen, white blood cell count, eosinophil count, and neutrophil count were not significantly different. In the multivariate analysis, the relative risk of infection was 2 [1.02; 4.5] (<i>p</i> = 0.04) for a PCT above 0.2 µg/L. In AAV, PCT may be useful for discriminating between infections and flare in patients suffering from AAVs. |
| first_indexed | 2024-03-11T06:26:40Z |
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| id | doaj.art-ffc7818e0ebc4fc5a0369e0641f7575d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:26:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ffc7818e0ebc4fc5a0369e0641f7575d2023-11-17T11:35:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246555710.3390/ijms24065557Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and InfectionsXavier Poirot-Seynaeve0Perrine Smets1Bruno Pereira2Louis Olagne3Julien Stievenart4Vincent Sapin5Olivier Aumaitre6Marc Andre7Ludovic Trefond8Médecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceBiostatistics Unit (DRCI), University Hospital Clermont-Ferrand, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceBiochemisty and Molecular Genetic Department, Biology Center, University Hospital Clermont-Ferrand, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceMédecine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, FranceProcalcitonin (PCT) was established as a biomarker to discriminate bacterial infections from other proinflammatory conditions. Our objective was to determine whether PCT is effective in differentiating infection from antineutrophil-cytoplasmic-antibody (ANCA)-associated vasculitides (AAV) flare. In this retrospective, case-control study, PCT and other inflammatory biomarkers of patients with AAV relapse (relapsing group) were compared to infected AAV patients (infected group). In our population of 74 patients with AAV, PCT was significantly higher in the infected group than in the relapsing group (0.2 µg/L [0.08; 0.935] vs. 0.09 µg/L [0.05; 0.2], <i>p</i> < 0.001). Sensitivity and specificity were 53.4% and 73.6%, respectively, for an ideal threshold of 0.2 µg/L. C-reactive protein (CRP) was significantly higher in cases of infection than in relapse (64.7 mg/L [25; 131] vs. 31.5 mg/L, [10.6; 120], <i>p</i> = 0.001). Sensitivity and specificity for infections were 94.2% and 11.3%, respectively. Fibrinogen, white blood cell count, eosinophil count, and neutrophil count were not significantly different. In the multivariate analysis, the relative risk of infection was 2 [1.02; 4.5] (<i>p</i> = 0.04) for a PCT above 0.2 µg/L. In AAV, PCT may be useful for discriminating between infections and flare in patients suffering from AAVs.https://www.mdpi.com/1422-0067/24/6/5557ANCA vasculitisprocalcitonininfection |
| spellingShingle | Xavier Poirot-Seynaeve Perrine Smets Bruno Pereira Louis Olagne Julien Stievenart Vincent Sapin Olivier Aumaitre Marc Andre Ludovic Trefond Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections International Journal of Molecular Sciences ANCA vasculitis procalcitonin infection |
| title | Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections |
| title_full | Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections |
| title_fullStr | Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections |
| title_full_unstemmed | Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections |
| title_short | Interest of Procalcitonin in ANCA Vasculitides for Differentiation between Flare and Infections |
| title_sort | interest of procalcitonin in anca vasculitides for differentiation between flare and infections |
| topic | ANCA vasculitis procalcitonin infection |
| url | https://www.mdpi.com/1422-0067/24/6/5557 |
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