Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes
Abstract Background The identification of circulating biomarkers associated with the risk of type 2 diabetes (T2D) is useful for improving the current prevention strategies in the most at-risk patients. Here, we aimed to investigate the association of plasma apolipoprotein concentrations in prediabe...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-02-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01452-5 |
| _version_ | 1818284242808864768 |
|---|---|
| author | Mikaël Croyal Matthieu Wargny Kevin Chemello Chloé Chevalier Valentin Blanchard Edith Bigot-Corbel Gilles Lambert Cédric Le May Samy Hadjadj Bertrand Cariou |
| author_facet | Mikaël Croyal Matthieu Wargny Kevin Chemello Chloé Chevalier Valentin Blanchard Edith Bigot-Corbel Gilles Lambert Cédric Le May Samy Hadjadj Bertrand Cariou |
| author_sort | Mikaël Croyal |
| collection | DOAJ |
| description | Abstract Background The identification of circulating biomarkers associated with the risk of type 2 diabetes (T2D) is useful for improving the current prevention strategies in the most at-risk patients. Here, we aimed to investigate the association of plasma apolipoprotein concentrations in prediabetes subjects with the incidence of new-onset T2D during follow-up. Methods In the IT-DIAB prospective study, 307 participants with impaired fasting glucose levels (fasting plasma glucose [FPG]: 110–125 mg/dL) were followed yearly for 5 years. The onset of T2D was defined as a first FPG value ≥ 126 mg/dL during follow-up. Apolipoprotein (apo)A-I, A-II, A-IV, B100, C-I, C-II, C-III, C-IV, D, E, F, H, J, L1, M, and (a) plasma concentrations were determined by mass spectrometry. Correlations between apolipoproteins and metabolic parameters at baseline were assessed by Spearman’s coefficients. Kaplan–Meier curves were drawn using a ternary approach based on terciles and incident T2D. The association between plasma apolipoproteins concentrations and the incidence of T2D was determined using Cox proportional-hazards models. Results During a median follow-up of 5-year, 115 participants (37.5%) developed T2D. After adjustment for age, sex, body mass index, FPG, HbA1c, and statin use, the plasma levels of apoC-I, apoC-II, apoC-III, apoE, apoF, apoH, apoJ, and apoL1 were positively associated with a high risk for T2D. After further adjustment for plasma triglycerides, only apoE (1 SD natural-log-transformed hazard ratio: 1.28 [95% confidence interval: 1.06; 1.54]; p = 0.010), apoF (1.22 [1.01; 1.48]; p = 0.037), apoJ (1.24 [1.03; 1.49]; p = 0.024), and apoL1 (1.26 [1.05; 1.52]; p = 0.014) remained significantly associated with the onset of T2D. Kaplan–Meier survival curves also showed that the lower third of plasma apoE levels (< 5.97 mg/dL) was significantly associated with a lower risk of conversion to T2D (log-rank test, p = 0.002) compared to the middle and upper thirds. Conclusions The plasma apoE levels are positively associated with the risk of T2D in prediabetes subjects, independently of traditional risk factors. The possible associations of apoF, apoJ, and apoL1 with T2D risk also pave the way for further investigations. Trial registration This trial was registered at clinicaltrials.gov as NCT01218061 and NCT01432509 |
| first_indexed | 2024-12-13T00:49:42Z |
| format | Article |
| id | doaj.art-ffc82ec9a5554c798820fecfb67c42c9 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-13T00:49:42Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ffc82ec9a5554c798820fecfb67c42c92022-12-22T00:04:57ZengBMCCardiovascular Diabetology1475-28402022-02-0121111110.1186/s12933-022-01452-5Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetesMikaël Croyal0Matthieu Wargny1Kevin Chemello2Chloé Chevalier3Valentin Blanchard4Edith Bigot-Corbel5Gilles Lambert6Cédric Le May7Samy Hadjadj8Bertrand Cariou9Nantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxNantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxUniversité de La Réunion, INSERM UMR 1188 DéTROINantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxDepartments of Medicine, Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul’s Hospital, University of British ColumbiaDepartment of Biochemistry, CHU Nantes, G et R Laënnec Hospital, Bd Jacques MonodUniversité de La Réunion, INSERM UMR 1188 DéTROINantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxNantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxNantes Université, CHU Nantes, CNRS, INSERM, l’institut du ThoraxAbstract Background The identification of circulating biomarkers associated with the risk of type 2 diabetes (T2D) is useful for improving the current prevention strategies in the most at-risk patients. Here, we aimed to investigate the association of plasma apolipoprotein concentrations in prediabetes subjects with the incidence of new-onset T2D during follow-up. Methods In the IT-DIAB prospective study, 307 participants with impaired fasting glucose levels (fasting plasma glucose [FPG]: 110–125 mg/dL) were followed yearly for 5 years. The onset of T2D was defined as a first FPG value ≥ 126 mg/dL during follow-up. Apolipoprotein (apo)A-I, A-II, A-IV, B100, C-I, C-II, C-III, C-IV, D, E, F, H, J, L1, M, and (a) plasma concentrations were determined by mass spectrometry. Correlations between apolipoproteins and metabolic parameters at baseline were assessed by Spearman’s coefficients. Kaplan–Meier curves were drawn using a ternary approach based on terciles and incident T2D. The association between plasma apolipoproteins concentrations and the incidence of T2D was determined using Cox proportional-hazards models. Results During a median follow-up of 5-year, 115 participants (37.5%) developed T2D. After adjustment for age, sex, body mass index, FPG, HbA1c, and statin use, the plasma levels of apoC-I, apoC-II, apoC-III, apoE, apoF, apoH, apoJ, and apoL1 were positively associated with a high risk for T2D. After further adjustment for plasma triglycerides, only apoE (1 SD natural-log-transformed hazard ratio: 1.28 [95% confidence interval: 1.06; 1.54]; p = 0.010), apoF (1.22 [1.01; 1.48]; p = 0.037), apoJ (1.24 [1.03; 1.49]; p = 0.024), and apoL1 (1.26 [1.05; 1.52]; p = 0.014) remained significantly associated with the onset of T2D. Kaplan–Meier survival curves also showed that the lower third of plasma apoE levels (< 5.97 mg/dL) was significantly associated with a lower risk of conversion to T2D (log-rank test, p = 0.002) compared to the middle and upper thirds. Conclusions The plasma apoE levels are positively associated with the risk of T2D in prediabetes subjects, independently of traditional risk factors. The possible associations of apoF, apoJ, and apoL1 with T2D risk also pave the way for further investigations. Trial registration This trial was registered at clinicaltrials.gov as NCT01218061 and NCT01432509https://doi.org/10.1186/s12933-022-01452-5New-onset diabetesType 2 diabetesApolipoproteinsApolipoprotein EIT-Diab study |
| spellingShingle | Mikaël Croyal Matthieu Wargny Kevin Chemello Chloé Chevalier Valentin Blanchard Edith Bigot-Corbel Gilles Lambert Cédric Le May Samy Hadjadj Bertrand Cariou Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes Cardiovascular Diabetology New-onset diabetes Type 2 diabetes Apolipoproteins Apolipoprotein E IT-Diab study |
| title | Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| title_full | Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| title_fullStr | Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| title_full_unstemmed | Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| title_short | Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| title_sort | plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes |
| topic | New-onset diabetes Type 2 diabetes Apolipoproteins Apolipoprotein E IT-Diab study |
| url | https://doi.org/10.1186/s12933-022-01452-5 |
| work_keys_str_mv | AT mikaelcroyal plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT matthieuwargny plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT kevinchemello plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT chloechevalier plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT valentinblanchard plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT edithbigotcorbel plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT gilleslambert plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT cedriclemay plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT samyhadjadj plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes AT bertrandcariou plasmaapolipoproteinconcentrationsandincidentdiabetesinsubjectswithprediabetes |