Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications
Abstract Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release of glutamate. The shared homology of sodium channels and lack of selectivity associate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.13311 |