Molecular basis of VEGFR1 autoinhibition at the plasma membrane

Molecular basis of VEGFR1 autoinhibition at the plasma membrane

Abstract Ligand-independent activation of VEGFRs is a hallmark of diabetes and several cancers. Like EGFR, VEGFR2 is activated spontaneously at high receptor concentrations. VEGFR1, on the other hand, remains constitutively inactive in the unligated state, making it an exception among VEGFRs. Ligand...

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Bibliographic Details
Main Authors: Manas Pratim Chakraborty, Diptatanu Das, Purav Mondal, Pragya Kaul, Soumi Bhattacharyya, Prosad Kumar Das, Rahul Das
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45499-2

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