Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants
The goal of this analysis is to identify risk factors for infantile hemangiomas (IH) to better delineate hemangioma predisposition. We analyzed live birth children with isolated cutaneous hemangioma that were reported to the Polish Registry of Congenital Malformations from across Poland between the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/7/10/150 |
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| author | Anna Materna-Kiryluk Katarzyna Wiśniewska Barbara Więckowska Katarzyna Wróblewska-Seniuk Beata Jaroszewska-Świątek Ewa Helwich Anna Latos-Bieleńska |
| author_facet | Anna Materna-Kiryluk Katarzyna Wiśniewska Barbara Więckowska Katarzyna Wróblewska-Seniuk Beata Jaroszewska-Świątek Ewa Helwich Anna Latos-Bieleńska |
| author_sort | Anna Materna-Kiryluk |
| collection | DOAJ |
| description | The goal of this analysis is to identify risk factors for infantile hemangiomas (IH) to better delineate hemangioma predisposition. We analyzed live birth children with isolated cutaneous hemangioma that were reported to the Polish Registry of Congenital Malformations from across Poland between the years 1998 and 2016. Lower birthweight and gestational age were the most significant risk factors associated with IH. We also observed a trend for a higher risk of IH with a lower level of maternal and paternal education. Moreover, mothers with IH have a higher probability of having a child with IH compared to fathers. However, this association is only present when the child is female. Similarly, a higher risk of hemangioma in a female child is found among mothers having relatives of the first degree with IH, compared to fathers with a similar pedigree. Our results suggest the role of exogenous factors in the etiology of IH. The analysis of familial cases suggests a multifactorial model of inheritance. The study indicates that female gender is an important risk factor for the expression of familial IH. Potential interaction of genetic risk factors with exposure to female sex hormones may play a role in the development of IH. |
| first_indexed | 2024-03-10T16:04:16Z |
| format | Article |
| id | doaj.art-ffcd906a7472408c883a5e13e81a9d95 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T16:04:16Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-ffcd906a7472408c883a5e13e81a9d952023-11-20T15:04:05ZengMDPI AGChildren2227-90672020-09-0171015010.3390/children7100150Genetic and Environmental Risk Factors for Isolated Hemangiomas in InfantsAnna Materna-Kiryluk0Katarzyna Wiśniewska1Barbara Więckowska2Katarzyna Wróblewska-Seniuk3Beata Jaroszewska-Świątek4Ewa Helwich5Anna Latos-Bieleńska6Polish Registry of Congenital Malformations, Chair and Department of Medical Genetics, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Preventive Medicine, Epidemiology Unit, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Newborns’ Infectious Diseases, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Children’s Hospital in Olsztyn, 10-651 Olsztyn, PolandDeparment of Neonatology and Neonatal Intensive Care, Institute of Mother and Child, 01-211 Warszawa, PolandPolish Registry of Congenital Malformations, Chair and Department of Medical Genetics, Poznan University of Medical Sciences, 61-701 Poznan, PolandThe goal of this analysis is to identify risk factors for infantile hemangiomas (IH) to better delineate hemangioma predisposition. We analyzed live birth children with isolated cutaneous hemangioma that were reported to the Polish Registry of Congenital Malformations from across Poland between the years 1998 and 2016. Lower birthweight and gestational age were the most significant risk factors associated with IH. We also observed a trend for a higher risk of IH with a lower level of maternal and paternal education. Moreover, mothers with IH have a higher probability of having a child with IH compared to fathers. However, this association is only present when the child is female. Similarly, a higher risk of hemangioma in a female child is found among mothers having relatives of the first degree with IH, compared to fathers with a similar pedigree. Our results suggest the role of exogenous factors in the etiology of IH. The analysis of familial cases suggests a multifactorial model of inheritance. The study indicates that female gender is an important risk factor for the expression of familial IH. Potential interaction of genetic risk factors with exposure to female sex hormones may play a role in the development of IH.https://www.mdpi.com/2227-9067/7/10/150infant hemangiomasrisk factorshereditary predispositionvascular malformations |
| spellingShingle | Anna Materna-Kiryluk Katarzyna Wiśniewska Barbara Więckowska Katarzyna Wróblewska-Seniuk Beata Jaroszewska-Świątek Ewa Helwich Anna Latos-Bieleńska Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants Children infant hemangiomas risk factors hereditary predisposition vascular malformations |
| title | Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants |
| title_full | Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants |
| title_fullStr | Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants |
| title_full_unstemmed | Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants |
| title_short | Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants |
| title_sort | genetic and environmental risk factors for isolated hemangiomas in infants |
| topic | infant hemangiomas risk factors hereditary predisposition vascular malformations |
| url | https://www.mdpi.com/2227-9067/7/10/150 |
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