Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease
AbstractBackground Renal dysfunction leads to poor prognosis of patients with coronary artery disease (CAD). Current studies have reported the prognosis or mortality of various diseases using different estimated glomerular filtrate rate (eGFR) formulas, while the performance of these equations is un...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2327494 |
| _version_ | 1797226327817846784 |
|---|---|
| author | Shiqun Chen Yang Zhou Guoxiao Liang Wanying Wu Zhigang Huang Lile Shi Yuwei Gao Xia Gu Dongmei Wang |
| author_facet | Shiqun Chen Yang Zhou Guoxiao Liang Wanying Wu Zhigang Huang Lile Shi Yuwei Gao Xia Gu Dongmei Wang |
| author_sort | Shiqun Chen |
| collection | DOAJ |
| description | AbstractBackground Renal dysfunction leads to poor prognosis of patients with coronary artery disease (CAD). Current studies have reported the prognosis or mortality of various diseases using different estimated glomerular filtrate rate (eGFR) formulas, while the performance of these equations is unclear in CAD patients. We aim to evaluate the predict effect of creatinine-based eGFR (eGFRcr), cystatin C-based eGFR (eGFRcys), and both creatinine and cystatin C-based eGFR (eGFRcr-cys) in CAD patients.Methods A total of 23,178 patients with CAD were included from CIN-II cohort study. The association of eGFRcr, eGFRcys and eGFRcr-cys with cardiovascular and all-cause mortality was detected by Cox regression analysis. The predictive effect of eGFRcr, eGFRcys and eGFRcr-cys on mortality was assessed.Results During a median follow up of 4.3 years, totally 2051 patients (8.8%) experience all-cause mortality, of which 1427 patients (6.2%) died of cardiovascular disease. For the detection of cardiovascular mortality among CAD patients, eGFRcr-cys had high discriminatory capacity with area under the curve (AUC) in receiver operator characteristic analysis of 0.730, which was significantly better than eGFRcr (AUC = 0.707, p < 0.001) and eGFRcys (AUC = 0.719, p < 0.001). Similar results were observed in all-cause mortality. Restricted cubic spline showed a U-shaped association between eGFRcr and all outcomes in patients with both reduced and supranormal eGFR levels, while a L-shaped association in eGFRcys and eGFRcr-cys.Conclusions Estimated GFR based on both creatinine and cystatin C has highest predictive effect for cardiovascular and all-cause mortality among CAD patients. Meanwhile, supranormal eGFRcr may indicate a higher risk of mortality. |
| first_indexed | 2024-04-24T14:23:09Z |
| format | Article |
| id | doaj.art-ffce6276b8df485a96d0403dc3d9da7f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T14:23:09Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-ffce6276b8df485a96d0403dc3d9da7f2024-04-03T06:10:21ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2327494Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery diseaseShiqun Chen0Yang Zhou1Guoxiao Liang2Wanying Wu3Zhigang Huang4Lile Shi5Yuwei Gao6Xia Gu7Dongmei Wang8Global Health Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Science, Guangzhou, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Southern Medical University, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Southern Medical University, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Southern Medical University, ChinaGuangdong Medical University, Dongguan, ChinaZhuhai People’s Hospital, Zhuhai hospital affiliated with Jinan University, Zhuhai, ChinaZhuhai People’s Hospital, Zhuhai hospital affiliated with Jinan University, Zhuhai, ChinaDepartment of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Cadres Health Management Center, Guangzhou, ChinaAbstractBackground Renal dysfunction leads to poor prognosis of patients with coronary artery disease (CAD). Current studies have reported the prognosis or mortality of various diseases using different estimated glomerular filtrate rate (eGFR) formulas, while the performance of these equations is unclear in CAD patients. We aim to evaluate the predict effect of creatinine-based eGFR (eGFRcr), cystatin C-based eGFR (eGFRcys), and both creatinine and cystatin C-based eGFR (eGFRcr-cys) in CAD patients.Methods A total of 23,178 patients with CAD were included from CIN-II cohort study. The association of eGFRcr, eGFRcys and eGFRcr-cys with cardiovascular and all-cause mortality was detected by Cox regression analysis. The predictive effect of eGFRcr, eGFRcys and eGFRcr-cys on mortality was assessed.Results During a median follow up of 4.3 years, totally 2051 patients (8.8%) experience all-cause mortality, of which 1427 patients (6.2%) died of cardiovascular disease. For the detection of cardiovascular mortality among CAD patients, eGFRcr-cys had high discriminatory capacity with area under the curve (AUC) in receiver operator characteristic analysis of 0.730, which was significantly better than eGFRcr (AUC = 0.707, p < 0.001) and eGFRcys (AUC = 0.719, p < 0.001). Similar results were observed in all-cause mortality. Restricted cubic spline showed a U-shaped association between eGFRcr and all outcomes in patients with both reduced and supranormal eGFR levels, while a L-shaped association in eGFRcys and eGFRcr-cys.Conclusions Estimated GFR based on both creatinine and cystatin C has highest predictive effect for cardiovascular and all-cause mortality among CAD patients. Meanwhile, supranormal eGFRcr may indicate a higher risk of mortality.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2327494Estimated glomerular filtrate ratecreatininecystatin Ccoronary artery disease |
| spellingShingle | Shiqun Chen Yang Zhou Guoxiao Liang Wanying Wu Zhigang Huang Lile Shi Yuwei Gao Xia Gu Dongmei Wang Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease Renal Failure Estimated glomerular filtrate rate creatinine cystatin C coronary artery disease |
| title | Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease |
| title_full | Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease |
| title_fullStr | Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease |
| title_full_unstemmed | Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease |
| title_short | Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease |
| title_sort | predictive effect of estimated glomerular filtrate rate by creatinine or cystatin c on mortality in patients with coronary artery disease |
| topic | Estimated glomerular filtrate rate creatinine cystatin C coronary artery disease |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2327494 |
| work_keys_str_mv | AT shiqunchen predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT yangzhou predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT guoxiaoliang predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT wanyingwu predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT zhiganghuang predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT lileshi predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT yuweigao predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT xiagu predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease AT dongmeiwang predictiveeffectofestimatedglomerularfiltrateratebycreatinineorcystatinconmortalityinpatientswithcoronaryarterydisease |