Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria
Background and purpose: There are clinical and histopathological similaritie between lichen planus (OLP) and oral lichenoid reactions (OLL) but they have different treatment approaches. The present study examined the correlation between clinical and histopathological findings in lichen planus and or...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://jmums.mazums.ac.ir/article-1-17570-en.html |
| _version_ | 1828002845177151488 |
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| author | Sajjad Emamipure Maryam Seyedmajidi Mina Motallebnejad Hemmat Golinia |
| author_facet | Sajjad Emamipure Maryam Seyedmajidi Mina Motallebnejad Hemmat Golinia |
| author_sort | Sajjad Emamipure |
| collection | DOAJ |
| description | Background and purpose: There are clinical and histopathological similaritie between lichen planus (OLP) and oral lichenoid reactions (OLL) but they have different treatment approaches. The present study examined the correlation between clinical and histopathological findings in lichen planus and oral lichenoid reaction based on modified WHO diagnostic criteria in order to evaluate using these criteria in differentiating these lesions.
Materials and methods: In this retrospective descriptive study, information, including clinical characteristics, age, sex, and histopathological characteristics were extracted from the clinical records of 101 OLP cases and 49 OLL cases. The paraffin block of biopsies was removed from the archives in pathology department and the prepared incision was stained with hematoxylin-eosin. The slides were examined by a pathologist and histopathological characteristics were recorded in a checklist. Data were analyzed by descriptive statistics, kappa score, Chi-square, and independent sample t-test.
Results: According to the 1978 diagnostic criteria, the agreement between clinical and histopathological diagnosis was 98.79% in OLP and 69.57% in OLL (P<0.001). According to the Modified WHO diagnostic criteria, the agreement between clinical and histopathological diagnosis was 99% in OLP and 71.43% in OLL (P<0.001).
Conclusion: In diagnosis of lichen planus and oral lichenoid reaction, there is a higher clinicopathologic correlation based on the modified WHO diagnostic criteria compared with the 1978 diagnostic criteria. Therefore, it is suggested to be used in clinical and histopathological investigations. |
| first_indexed | 2024-04-10T06:49:01Z |
| format | Article |
| id | doaj.art-ffcecd78fb494ccd831263530a725f32 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:01Z |
| publishDate | 2022-10-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-ffcecd78fb494ccd831263530a725f322023-02-28T09:08:45ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-10-0132213103113Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic CriteriaSajjad Emamipure0Maryam Seyedmajidi1Mina Motallebnejad2Hemmat Golinia3 Dentist, Student Research Committee, Babol University of Medical Sciences, Babol, Iran Professor, Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Professor, Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran MSc in Statistics, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Background and purpose: There are clinical and histopathological similaritie between lichen planus (OLP) and oral lichenoid reactions (OLL) but they have different treatment approaches. The present study examined the correlation between clinical and histopathological findings in lichen planus and oral lichenoid reaction based on modified WHO diagnostic criteria in order to evaluate using these criteria in differentiating these lesions. Materials and methods: In this retrospective descriptive study, information, including clinical characteristics, age, sex, and histopathological characteristics were extracted from the clinical records of 101 OLP cases and 49 OLL cases. The paraffin block of biopsies was removed from the archives in pathology department and the prepared incision was stained with hematoxylin-eosin. The slides were examined by a pathologist and histopathological characteristics were recorded in a checklist. Data were analyzed by descriptive statistics, kappa score, Chi-square, and independent sample t-test. Results: According to the 1978 diagnostic criteria, the agreement between clinical and histopathological diagnosis was 98.79% in OLP and 69.57% in OLL (P<0.001). According to the Modified WHO diagnostic criteria, the agreement between clinical and histopathological diagnosis was 99% in OLP and 71.43% in OLL (P<0.001). Conclusion: In diagnosis of lichen planus and oral lichenoid reaction, there is a higher clinicopathologic correlation based on the modified WHO diagnostic criteria compared with the 1978 diagnostic criteria. Therefore, it is suggested to be used in clinical and histopathological investigations.http://jmums.mazums.ac.ir/article-1-17570-en.htmloral lichen planusoral lichenoidmodified who diagnostic criteria |
| spellingShingle | Sajjad Emamipure Maryam Seyedmajidi Mina Motallebnejad Hemmat Golinia Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria Journal of Mazandaran University of Medical Sciences oral lichen planus oral lichenoid modified who diagnostic criteria |
| title | Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria |
| title_full | Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria |
| title_fullStr | Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria |
| title_full_unstemmed | Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria |
| title_short | Correlation between Clinical and Histopathological Findings in Oral Lichen Planus and Oral Lichenoid Reactions Based on Modified WHO Diagnostic Criteria |
| title_sort | correlation between clinical and histopathological findings in oral lichen planus and oral lichenoid reactions based on modified who diagnostic criteria |
| topic | oral lichen planus oral lichenoid modified who diagnostic criteria |
| url | http://jmums.mazums.ac.ir/article-1-17570-en.html |
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