Updated scientific opinion on plants developed through cisgenesis and intragenesis
Abstract In 2012, EFSA issued an opinion on plants developed through cisgenesis and intragenesis. With the development of New Genomic Techniques (NGTs) in the last decade, cisgenic and intragenic plants can now be obtained with the insertion of a desired sequence in a precise location of the genome....
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2022.7621 |
| _version_ | 1811324713235906560 |
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| author | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Josep Casacuberta Antonio Fernandez Dumont Andrea Gennaro Paolo Lenzi Aleksandra Lewandowska Irene Pilar Munoz Guajardo Nikoletta Papadopoulou Nils Rostoks |
| author_facet | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Josep Casacuberta Antonio Fernandez Dumont Andrea Gennaro Paolo Lenzi Aleksandra Lewandowska Irene Pilar Munoz Guajardo Nikoletta Papadopoulou Nils Rostoks |
| author_sort | EFSA Panel on Genetically Modified Organisms (GMO) |
| collection | DOAJ |
| description | Abstract In 2012, EFSA issued an opinion on plants developed through cisgenesis and intragenesis. With the development of New Genomic Techniques (NGTs) in the last decade, cisgenic and intragenic plants can now be obtained with the insertion of a desired sequence in a precise location of the genome. EFSA has been requested by European Commission to provide an updated scientific opinion on the safety and the risk assessment of plants developed through cisgenesis and intragenesis, in order to (i) identify potential risks, comparing them with those posed by plants obtained by conventional breeding and Established Genomic Techniques (EGTs) and (ii) to determine the applicability of current guidelines for the risk assessment of cisgenic and intragenic plants. The conclusions of the previous EFSA opinion were reviewed, taking into consideration the new guidelines and the recent literature. The GMO panel concludes that no new risks are identified in cisgenic and intragenic plants obtained with NGTs, as compared with those already considered for plants obtained with conventional breeding and EGTs. There are no new data since the publication of the 2012 EFSA opinion that would challenge the conclusions raised in that document. The conclusions of the EFSA 2012 Scientific Opinion remain valid. The EFSA GMO Panel reiterates from these conclusions that with respect to the source of DNA and the safety of the gene product, the hazards arising from the use of a related plant‐derived gene by cisgenesis are similar to those from conventional plant breeding, whereas additional hazards may arise for intragenic plants. Furthermore, the EFSA GMO Panel considers that cisgenesis and intragenesis make use of the same transformation techniques as transgenesis, and therefore, with respect to the alterations to the host genome, cisgenic, intragenic and transgenic plants obtained by random insertion do not cause different hazards. Compared to that, the use of NGTs reduces the risks associated with potential unintended modifications of the host genome. Thus, fewer requirements may be needed for the assessment of cisgenic and intragenic plants obtained through NGTs, due to site‐directed integration of the added genetic material. Moreover, the GMO panel concludes that the current guidelines are partially applicable and sufficient. On a case‐by‐case basis, a lesser amount of data might be needed for the risk assessment of cisgenic or intragenic plants obtained through NGTs. |
| first_indexed | 2024-04-13T14:20:22Z |
| format | Article |
| id | doaj.art-ffcfa141da0f46598bb1bc651b562048 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-04-13T14:20:22Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-ffcfa141da0f46598bb1bc651b5620482022-12-22T02:43:31ZengWileyEFSA Journal1831-47322022-10-012010n/an/a10.2903/j.efsa.2022.7621Updated scientific opinion on plants developed through cisgenesis and intragenesisEFSA Panel on Genetically Modified Organisms (GMO)Ewen MullinsJean‐Louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoHanspeter NaegeliFabien NoguéJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiJosep CasacubertaAntonio Fernandez DumontAndrea GennaroPaolo LenziAleksandra LewandowskaIrene Pilar Munoz GuajardoNikoletta PapadopoulouNils RostoksAbstract In 2012, EFSA issued an opinion on plants developed through cisgenesis and intragenesis. With the development of New Genomic Techniques (NGTs) in the last decade, cisgenic and intragenic plants can now be obtained with the insertion of a desired sequence in a precise location of the genome. EFSA has been requested by European Commission to provide an updated scientific opinion on the safety and the risk assessment of plants developed through cisgenesis and intragenesis, in order to (i) identify potential risks, comparing them with those posed by plants obtained by conventional breeding and Established Genomic Techniques (EGTs) and (ii) to determine the applicability of current guidelines for the risk assessment of cisgenic and intragenic plants. The conclusions of the previous EFSA opinion were reviewed, taking into consideration the new guidelines and the recent literature. The GMO panel concludes that no new risks are identified in cisgenic and intragenic plants obtained with NGTs, as compared with those already considered for plants obtained with conventional breeding and EGTs. There are no new data since the publication of the 2012 EFSA opinion that would challenge the conclusions raised in that document. The conclusions of the EFSA 2012 Scientific Opinion remain valid. The EFSA GMO Panel reiterates from these conclusions that with respect to the source of DNA and the safety of the gene product, the hazards arising from the use of a related plant‐derived gene by cisgenesis are similar to those from conventional plant breeding, whereas additional hazards may arise for intragenic plants. Furthermore, the EFSA GMO Panel considers that cisgenesis and intragenesis make use of the same transformation techniques as transgenesis, and therefore, with respect to the alterations to the host genome, cisgenic, intragenic and transgenic plants obtained by random insertion do not cause different hazards. Compared to that, the use of NGTs reduces the risks associated with potential unintended modifications of the host genome. Thus, fewer requirements may be needed for the assessment of cisgenic and intragenic plants obtained through NGTs, due to site‐directed integration of the added genetic material. Moreover, the GMO panel concludes that the current guidelines are partially applicable and sufficient. On a case‐by‐case basis, a lesser amount of data might be needed for the risk assessment of cisgenic or intragenic plants obtained through NGTs.https://doi.org/10.2903/j.efsa.2022.7621cisgenesisintragenesisplantsgenome editingnew genomic techniquessite‐directed nucleases |
| spellingShingle | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Josep Casacuberta Antonio Fernandez Dumont Andrea Gennaro Paolo Lenzi Aleksandra Lewandowska Irene Pilar Munoz Guajardo Nikoletta Papadopoulou Nils Rostoks Updated scientific opinion on plants developed through cisgenesis and intragenesis EFSA Journal cisgenesis intragenesis plants genome editing new genomic techniques site‐directed nucleases |
| title | Updated scientific opinion on plants developed through cisgenesis and intragenesis |
| title_full | Updated scientific opinion on plants developed through cisgenesis and intragenesis |
| title_fullStr | Updated scientific opinion on plants developed through cisgenesis and intragenesis |
| title_full_unstemmed | Updated scientific opinion on plants developed through cisgenesis and intragenesis |
| title_short | Updated scientific opinion on plants developed through cisgenesis and intragenesis |
| title_sort | updated scientific opinion on plants developed through cisgenesis and intragenesis |
| topic | cisgenesis intragenesis plants genome editing new genomic techniques site‐directed nucleases |
| url | https://doi.org/10.2903/j.efsa.2022.7621 |
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