Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/10/8805 |
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| author | Zufeng Wang Chengliang Luo Edward W. Zhou Aaron F. Sandhu Xiaojing Yuan George E. Williams Jialu Cheng Bharati Sinha Mohammed Akbar Pallab Bhattacharya Shuanhu Zhou Byoung-Joon Song Xin Wang |
| author_facet | Zufeng Wang Chengliang Luo Edward W. Zhou Aaron F. Sandhu Xiaojing Yuan George E. Williams Jialu Cheng Bharati Sinha Mohammed Akbar Pallab Bhattacharya Shuanhu Zhou Byoung-Joon Song Xin Wang |
| author_sort | Zufeng Wang |
| collection | DOAJ |
| description | The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities. |
| first_indexed | 2024-03-11T03:40:09Z |
| format | Article |
| id | doaj.art-ffcfb2da7dfb419ab828ba73df1fd12a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:40:09Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ffcfb2da7dfb419ab828ba73df1fd12a2023-11-18T01:42:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410880510.3390/ijms24108805Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain InjuryZufeng Wang0Chengliang Luo1Edward W. Zhou2Aaron F. Sandhu3Xiaojing Yuan4George E. Williams5Jialu Cheng6Bharati Sinha7Mohammed Akbar8Pallab Bhattacharya9Shuanhu Zhou10Byoung-Joon Song11Xin Wang12Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USADepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar 382355, Gujarat, IndiaHarvard Medical School, Harvard Stem Cell Institute, Boston, MA 02115, USASection of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAThe increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.https://www.mdpi.com/1422-0067/24/10/8805alcohol use disorderpost-traumatic stress disordertraumatic brain injurycomorbiditycharacteristicsmolecular toxicology |
| spellingShingle | Zufeng Wang Chengliang Luo Edward W. Zhou Aaron F. Sandhu Xiaojing Yuan George E. Williams Jialu Cheng Bharati Sinha Mohammed Akbar Pallab Bhattacharya Shuanhu Zhou Byoung-Joon Song Xin Wang Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury International Journal of Molecular Sciences alcohol use disorder post-traumatic stress disorder traumatic brain injury comorbidity characteristics molecular toxicology |
| title | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
| title_full | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
| title_fullStr | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
| title_full_unstemmed | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
| title_short | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
| title_sort | molecular toxicology and pathophysiology of comorbid alcohol use disorder and post traumatic stress disorder associated with traumatic brain injury |
| topic | alcohol use disorder post-traumatic stress disorder traumatic brain injury comorbidity characteristics molecular toxicology |
| url | https://www.mdpi.com/1422-0067/24/10/8805 |
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