Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity
The inability to meet and ensure as many requirements as possible is fully justified by the continuous interest in obtaining new multifunctional materials. A new cryogel system based on poly(vinyl alcohol) (PVA) and poly(ethylene brassylate-co-squaric acid) (PEBSA) obtained by repeated freeze–thaw p...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/3/174 |
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| author | Bianca-Elena-Beatrice Crețu Alina Gabriela Rusu Alina Ghilan Irina Rosca Loredana Elena Nita Aurica P. Chiriac |
| author_facet | Bianca-Elena-Beatrice Crețu Alina Gabriela Rusu Alina Ghilan Irina Rosca Loredana Elena Nita Aurica P. Chiriac |
| author_sort | Bianca-Elena-Beatrice Crețu |
| collection | DOAJ |
| description | The inability to meet and ensure as many requirements as possible is fully justified by the continuous interest in obtaining new multifunctional materials. A new cryogel system based on poly(vinyl alcohol) (PVA) and poly(ethylene brassylate-co-squaric acid) (PEBSA) obtained by repeated freeze–thaw processes was previously reported and used for the incorporation of an antibacterial essential oil—namely, thymol (Thy). Furthermore, the present study aims to confer antioxidant properties to the PVA/PEBSA_Thy system by encapsulating α-tocopherol (α-Tcp), targeting a double therapeutic effect due to the presence of both bioactive compounds. The amphiphilic nature of the PEBSA copolymer allowed for the encapsulation of both Thy and α-Tcp, via an in situ entrapment method. The new PVA/PEBSA_Thy_α-Tcp systems were characterized in terms of their influence on the composition, network morphology and release profiles, as well as their antimicrobial and antioxidant properties. The study underlined the cumulative antioxidant efficiency of Thy and α-Tcp, which in combination with the PEBSA copolymer have a synergistic effect (97.1%). We believe that the convenient and simple strategy offered in this study increases applicability for these new PVA/PEBSA_Thy_α-Tcp cryogel systems. |
| first_indexed | 2024-03-11T06:31:35Z |
| format | Article |
| id | doaj.art-ffd058c5d1d14827b35c3a6f0d071444 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T06:31:35Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-ffd058c5d1d14827b35c3a6f0d0714442023-11-17T11:14:17ZengMDPI AGGels2310-28612023-02-019317410.3390/gels9030174Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive ActivityBianca-Elena-Beatrice Crețu0Alina Gabriela Rusu1Alina Ghilan2Irina Rosca3Loredana Elena Nita4Aurica P. Chiriac5Department of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaDepartment of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaDepartment of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaCenter of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaDepartment of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaDepartment of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaThe inability to meet and ensure as many requirements as possible is fully justified by the continuous interest in obtaining new multifunctional materials. A new cryogel system based on poly(vinyl alcohol) (PVA) and poly(ethylene brassylate-co-squaric acid) (PEBSA) obtained by repeated freeze–thaw processes was previously reported and used for the incorporation of an antibacterial essential oil—namely, thymol (Thy). Furthermore, the present study aims to confer antioxidant properties to the PVA/PEBSA_Thy system by encapsulating α-tocopherol (α-Tcp), targeting a double therapeutic effect due to the presence of both bioactive compounds. The amphiphilic nature of the PEBSA copolymer allowed for the encapsulation of both Thy and α-Tcp, via an in situ entrapment method. The new PVA/PEBSA_Thy_α-Tcp systems were characterized in terms of their influence on the composition, network morphology and release profiles, as well as their antimicrobial and antioxidant properties. The study underlined the cumulative antioxidant efficiency of Thy and α-Tcp, which in combination with the PEBSA copolymer have a synergistic effect (97.1%). We believe that the convenient and simple strategy offered in this study increases applicability for these new PVA/PEBSA_Thy_α-Tcp cryogel systems.https://www.mdpi.com/2310-2861/9/3/174poly(vinyl alcohol)copolymacrolactonethymolα-tocopherolsynergistic effecthydrogel dressings |
| spellingShingle | Bianca-Elena-Beatrice Crețu Alina Gabriela Rusu Alina Ghilan Irina Rosca Loredana Elena Nita Aurica P. Chiriac Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity Gels poly(vinyl alcohol) copolymacrolactone thymol α-tocopherol synergistic effect hydrogel dressings |
| title | Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity |
| title_full | Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity |
| title_fullStr | Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity |
| title_full_unstemmed | Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity |
| title_short | Cryogel System Based on Poly(vinyl alcohol)/Poly(ethylene brassylate-co-squaric acid) Platform with Dual Bioactive Activity |
| title_sort | cryogel system based on poly vinyl alcohol poly ethylene brassylate co squaric acid platform with dual bioactive activity |
| topic | poly(vinyl alcohol) copolymacrolactone thymol α-tocopherol synergistic effect hydrogel dressings |
| url | https://www.mdpi.com/2310-2861/9/3/174 |
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