Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium
Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00553-0 |
| _version_ | 1818423144418902016 |
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| author | Cayla E. Jewett Timothy E. Vanderleest Hui Miao Yi Xie Roopa Madhu Dinah Loerke J. Todd Blankenship |
| author_facet | Cayla E. Jewett Timothy E. Vanderleest Hui Miao Yi Xie Roopa Madhu Dinah Loerke J. Todd Blankenship |
| author_sort | Cayla E. Jewett |
| collection | DOAJ |
| description | Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells. |
| first_indexed | 2024-12-14T13:37:29Z |
| format | Article |
| id | doaj.art-ffd112e8fb114efa851ecacc98fe3c75 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:37:29Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ffd112e8fb114efa851ecacc98fe3c752022-12-21T22:59:33ZengNature PortfolioNature Communications2041-17232017-09-018111610.1038/s41467-017-00553-0Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epitheliumCayla E. Jewett0Timothy E. Vanderleest1Hui Miao2Yi Xie3Roopa Madhu4Dinah Loerke5J. Todd Blankenship6Department of Biological Sciences, University of DenverDepartment of Physics, University of DenverDepartment of Biological Sciences, University of DenverDepartment of Biological Sciences, University of DenverDepartment of Physics, University of DenverDepartment of Physics, University of DenverDepartment of Biological Sciences, University of DenverVarious stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells.https://doi.org/10.1038/s41467-017-00553-0 |
| spellingShingle | Cayla E. Jewett Timothy E. Vanderleest Hui Miao Yi Xie Roopa Madhu Dinah Loerke J. Todd Blankenship Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium Nature Communications |
| title | Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium |
| title_full | Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium |
| title_fullStr | Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium |
| title_full_unstemmed | Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium |
| title_short | Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium |
| title_sort | planar polarized rab35 functions as an oscillatory ratchet during cell intercalation in the drosophila epithelium |
| url | https://doi.org/10.1038/s41467-017-00553-0 |
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