The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding proteins recognise the m6A modification to re...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.869950/full |
| _version_ | 1811299971615424512 |
|---|---|
| author | Jin Sun Jin Sun Bokai Cheng Bokai Cheng Yongkang Su Yongkang Su Man Li Man Li Shouyuan Ma Yan Zhang Anhang Zhang Anhang Zhang Shuang Cai Shuang Cai Qiligeer Bao Qiligeer Bao Shuxia Wang Shuxia Wang Ping Zhu Ping Zhu |
| author_facet | Jin Sun Jin Sun Bokai Cheng Bokai Cheng Yongkang Su Yongkang Su Man Li Man Li Shouyuan Ma Yan Zhang Anhang Zhang Anhang Zhang Shuang Cai Shuang Cai Qiligeer Bao Qiligeer Bao Shuxia Wang Shuxia Wang Ping Zhu Ping Zhu |
| author_sort | Jin Sun |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding proteins recognise the m6A modification to regulate gene expression. Recent studies have shown that altered m6A levels and abnormal regulator expression are crucial in the ageing process and the occurrence of age-related diseases. In this review, we summarise some key findings in the field of m6A modification in the ageing process and age-related diseases, including cell senescence, autophagy, inflammation, oxidative stress, DNA damage, tumours, neurodegenerative diseases, diabetes, and cardiovascular diseases (CVDs). We focused on the biological function and potential molecular mechanisms of m6A RNA methylation in ageing and age-related disease progression. We believe that m6A modification may provide a new target for anti-ageing therapies. |
| first_indexed | 2024-04-13T06:44:24Z |
| format | Article |
| id | doaj.art-ffd126eb08a9430d8230f8956b56ad74 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T06:44:24Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ffd126eb08a9430d8230f8956b56ad742022-12-22T02:57:39ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.869950869950The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated DiseasesJin Sun0Jin Sun1Bokai Cheng2Bokai Cheng3Yongkang Su4Yongkang Su5Man Li6Man Li7Shouyuan Ma8Yan Zhang9Anhang Zhang10Anhang Zhang11Shuang Cai12Shuang Cai13Qiligeer Bao14Qiligeer Bao15Shuxia Wang16Shuxia Wang17Ping Zhu18Ping Zhu19Department of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatric Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Outpatient, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaN6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding proteins recognise the m6A modification to regulate gene expression. Recent studies have shown that altered m6A levels and abnormal regulator expression are crucial in the ageing process and the occurrence of age-related diseases. In this review, we summarise some key findings in the field of m6A modification in the ageing process and age-related diseases, including cell senescence, autophagy, inflammation, oxidative stress, DNA damage, tumours, neurodegenerative diseases, diabetes, and cardiovascular diseases (CVDs). We focused on the biological function and potential molecular mechanisms of m6A RNA methylation in ageing and age-related disease progression. We believe that m6A modification may provide a new target for anti-ageing therapies.https://www.frontiersin.org/articles/10.3389/fgene.2022.869950/fullN6-methyladenosineagingaging-related diseaseepigeneticsRNA methylation |
| spellingShingle | Jin Sun Jin Sun Bokai Cheng Bokai Cheng Yongkang Su Yongkang Su Man Li Man Li Shouyuan Ma Yan Zhang Anhang Zhang Anhang Zhang Shuang Cai Shuang Cai Qiligeer Bao Qiligeer Bao Shuxia Wang Shuxia Wang Ping Zhu Ping Zhu The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases Frontiers in Genetics N6-methyladenosine aging aging-related disease epigenetics RNA methylation |
| title | The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases |
| title_full | The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases |
| title_fullStr | The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases |
| title_full_unstemmed | The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases |
| title_short | The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases |
| title_sort | potential role of m6a rna methylation in the aging process and aging associated diseases |
| topic | N6-methyladenosine aging aging-related disease epigenetics RNA methylation |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.869950/full |
| work_keys_str_mv | AT jinsun thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT jinsun thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT bokaicheng thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT bokaicheng thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yongkangsu thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yongkangsu thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT manli thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT manli thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shouyuanma thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yanzhang thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT anhangzhang thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT anhangzhang thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuangcai thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuangcai thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT qiligeerbao thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT qiligeerbao thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuxiawang thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuxiawang thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT pingzhu thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT pingzhu thepotentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT jinsun potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT jinsun potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT bokaicheng potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT bokaicheng potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yongkangsu potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yongkangsu potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT manli potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT manli potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shouyuanma potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT yanzhang potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT anhangzhang potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT anhangzhang potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuangcai potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuangcai potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT qiligeerbao potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT qiligeerbao potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuxiawang potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT shuxiawang potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT pingzhu potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases AT pingzhu potentialroleofm6arnamethylationintheagingprocessandagingassociateddiseases |