Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report
We report the case of a 43-year-old woman with primary left breast cancer presenting metastatic lymphadenopathy in the contralateral axilla. This patient represents a diagnostic and therapeutic challenge because primary breast cancer, occult contralateral breast cancer, and extra-mammary primary les...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2015-11-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/440662 |
| _version_ | 1811307984649715712 |
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| author | Yong Gi Son Woon Won Kim Ki Hoon Kim Jin Soo Kim |
| author_facet | Yong Gi Son Woon Won Kim Ki Hoon Kim Jin Soo Kim |
| author_sort | Yong Gi Son |
| collection | DOAJ |
| description | We report the case of a 43-year-old woman with primary left breast cancer presenting metastatic lymphadenopathy in the contralateral axilla. This patient represents a diagnostic and therapeutic challenge because primary breast cancer, occult contralateral breast cancer, and extra-mammary primary lesion can all be the source of the contralateral axillary metastasis. Left breast-conserving surgery, left sentinel lymph node biopsy, right breast mass excision, and right axillary lymph node dissection were performed. Immunohistochemical analysis revealed that the left breast cancer specimen was positive for estrogen receptor (ER) and progesterone receptor (PR), but negative for human epidermal growth factor receptor 2 (HER2). In contrast, the right axillary lymphadenopathy specimen was negative for ER and PR, but positive for HER2. Further investigation revealed no evidence of occult primary cancers or extra-mammary tumors. After surgical intervention, the patient was treated with adjuvant chemotherapy, adjuvant radiation therapy, and targeted therapy with trastuzumab. Two years after diagnosis, she is free of disease and presently being treated with tamoxifen. |
| first_indexed | 2024-04-13T09:15:05Z |
| format | Article |
| id | doaj.art-ffd4ef6df7f746e59b691a69b0ec948c |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T09:15:05Z |
| publishDate | 2015-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-ffd4ef6df7f746e59b691a69b0ec948c2022-12-22T02:52:46ZengKarger PublishersCase Reports in Oncology1662-65752015-11-018349850210.1159/000440662440662Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case ReportYong Gi SonWoon Won KimKi Hoon KimJin Soo KimWe report the case of a 43-year-old woman with primary left breast cancer presenting metastatic lymphadenopathy in the contralateral axilla. This patient represents a diagnostic and therapeutic challenge because primary breast cancer, occult contralateral breast cancer, and extra-mammary primary lesion can all be the source of the contralateral axillary metastasis. Left breast-conserving surgery, left sentinel lymph node biopsy, right breast mass excision, and right axillary lymph node dissection were performed. Immunohistochemical analysis revealed that the left breast cancer specimen was positive for estrogen receptor (ER) and progesterone receptor (PR), but negative for human epidermal growth factor receptor 2 (HER2). In contrast, the right axillary lymphadenopathy specimen was negative for ER and PR, but positive for HER2. Further investigation revealed no evidence of occult primary cancers or extra-mammary tumors. After surgical intervention, the patient was treated with adjuvant chemotherapy, adjuvant radiation therapy, and targeted therapy with trastuzumab. Two years after diagnosis, she is free of disease and presently being treated with tamoxifen.http://www.karger.com/Article/FullText/440662ImmunohistochemistryBreast carcinomaOccult primary tumorContralateral axillary lymph node metastasis |
| spellingShingle | Yong Gi Son Woon Won Kim Ki Hoon Kim Jin Soo Kim Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report Case Reports in Oncology Immunohistochemistry Breast carcinoma Occult primary tumor Contralateral axillary lymph node metastasis |
| title | Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report |
| title_full | Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report |
| title_fullStr | Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report |
| title_full_unstemmed | Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report |
| title_short | Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report |
| title_sort | is it contralateral axillary metastasis or occult breast cancer a confusing case report |
| topic | Immunohistochemistry Breast carcinoma Occult primary tumor Contralateral axillary lymph node metastasis |
| url | http://www.karger.com/Article/FullText/440662 |
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