The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely independent ro...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2008-04-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4467 |
| Summary: | Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely
independent routes: the mevalonate and the non-mevalonate pathway. While the former is used by humans, the latter is employed exclusively by a number of important pathogens such as the malarial Plasmodium falciparum parasite or the tuberculosis-causing Mycobacterium tuberculosis
bacterium. Hence, the constituent enzymes are potentially very interesting drug targets in the ongoing fight against diseases, whose treatment has been complicated by the emergence of multi-drug resistance. After a short description of the biosynthetic pathway, an overview will be given on
the known inhibitors of the individual enzymes.
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| ISSN: | 0009-4293 2673-2424 |