The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely independent ro...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2008-04-01
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| Series: | CHIMIA |
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| Online Access: | https://chimia.ch/chimia/article/view/4467 |
| _version_ | 1811320105272868864 |
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| author | Anna K. H. Hirsch François Diederich |
| author_facet | Anna K. H. Hirsch François Diederich |
| author_sort | Anna K. H. Hirsch |
| collection | DOAJ |
| description |
Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely
independent routes: the mevalonate and the non-mevalonate pathway. While the former is used by humans, the latter is employed exclusively by a number of important pathogens such as the malarial Plasmodium falciparum parasite or the tuberculosis-causing Mycobacterium tuberculosis
bacterium. Hence, the constituent enzymes are potentially very interesting drug targets in the ongoing fight against diseases, whose treatment has been complicated by the emergence of multi-drug resistance. After a short description of the biosynthetic pathway, an overview will be given on
the known inhibitors of the individual enzymes.
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| first_indexed | 2024-04-13T12:53:32Z |
| format | Article |
| id | doaj.art-ffd56c7f0b7b4a73bcc380e227748226 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T12:53:32Z |
| publishDate | 2008-04-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-ffd56c7f0b7b4a73bcc380e2277482262022-12-22T02:46:08ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242008-04-0162410.2533/chimia.2008.226The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug TargetsAnna K. H. HirschFrançois Diederich Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely independent routes: the mevalonate and the non-mevalonate pathway. While the former is used by humans, the latter is employed exclusively by a number of important pathogens such as the malarial Plasmodium falciparum parasite or the tuberculosis-causing Mycobacterium tuberculosis bacterium. Hence, the constituent enzymes are potentially very interesting drug targets in the ongoing fight against diseases, whose treatment has been complicated by the emergence of multi-drug resistance. After a short description of the biosynthetic pathway, an overview will be given on the known inhibitors of the individual enzymes. https://chimia.ch/chimia/article/view/4467Anti-infective agentsDrug designInhibitorsIsoprenoid biosynthesisNon-mevalonate pathway |
| spellingShingle | Anna K. H. Hirsch François Diederich The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets CHIMIA Anti-infective agents Drug design Inhibitors Isoprenoid biosynthesis Non-mevalonate pathway |
| title | The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets |
| title_full | The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets |
| title_fullStr | The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets |
| title_full_unstemmed | The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets |
| title_short | The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets |
| title_sort | non mevalonate pathway to isoprenoid biosynthesis a potential source of new drug targets |
| topic | Anti-infective agents Drug design Inhibitors Isoprenoid biosynthesis Non-mevalonate pathway |
| url | https://chimia.ch/chimia/article/view/4467 |
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