Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching

Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a potent humoral immune response in preclinical and clinical studies. In addition, in preclinical...

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Bibliographic Details
Main Authors: Diego Piccioli, Francesca Buricchi, Marta Bacconi, Nicoletta Bechi, Barbara Galli, Francesca Ferlicca, Enrico Luzzi, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Silvana Savino, Brunella Brunelli, Erika Bartolini, Francesca Micoli
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Vaccines
Subjects:
GMMA
antigen carrier
humoral immune response
enhancement
affinity maturation
isotype switching
Online Access:https://www.mdpi.com/2076-393X/11/7/1219

Internet

https://www.mdpi.com/2076-393X/11/7/1219

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