The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal isch...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2013-01-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002&tlng=en |
| _version_ | 1819125787965521920 |
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| author | Vera Lucia Fernandes de Azevedo Paulo Sergio Santana Santos Gildàsio Silveira de Oliveira Jr Gabriel Pinheiro Módolo Maria Aparecida Custódio Domingues Yara Marcondes Machado Castiglia Pedro Thadeu Galvão Vianna Luiz Antonio Vane Norma Sueli Pinheiro Módolo |
| author_facet | Vera Lucia Fernandes de Azevedo Paulo Sergio Santana Santos Gildàsio Silveira de Oliveira Jr Gabriel Pinheiro Módolo Maria Aparecida Custódio Domingues Yara Marcondes Machado Castiglia Pedro Thadeu Galvão Vianna Luiz Antonio Vane Norma Sueli Pinheiro Módolo |
| author_sort | Vera Lucia Fernandes de Azevedo |
| collection | DOAJ |
| description | PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. |
| first_indexed | 2024-12-22T07:45:42Z |
| format | Article |
| id | doaj.art-ffd6e55c134042ca830403576a38ce96 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T07:45:42Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-ffd6e55c134042ca830403576a38ce962022-12-21T18:33:39ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502013-01-01281050910.1590/S0102-86502013000100002The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsVera Lucia Fernandes de Azevedo0Paulo Sergio Santana Santos1Gildàsio Silveira de Oliveira Jr2Gabriel Pinheiro Módolo3Maria Aparecida Custódio Domingues4Yara Marcondes Machado Castiglia5Pedro Thadeu Galvão Vianna6Luiz Antonio Vane7Norma Sueli Pinheiro Módolo8Universidade Estadual PaulistaUniversidade Estadual PaulistaNorthwestern UniversityFaculdade de Ciências Médicas da Santa Casa de São PauloUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002&tlng=enAcute Kidney InjuryFluid TherapyColloidsHetastarchRats |
| spellingShingle | Vera Lucia Fernandes de Azevedo Paulo Sergio Santana Santos Gildàsio Silveira de Oliveira Jr Gabriel Pinheiro Módolo Maria Aparecida Custódio Domingues Yara Marcondes Machado Castiglia Pedro Thadeu Galvão Vianna Luiz Antonio Vane Norma Sueli Pinheiro Módolo The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats Acta Cirúrgica Brasileira Acute Kidney Injury Fluid Therapy Colloids Hetastarch Rats |
| title | The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
| title_full | The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
| title_fullStr | The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
| title_full_unstemmed | The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
| title_short | The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats |
| title_sort | effect of 6 hydroxyethyl starch vs ringer s lactate on acute kidney injury after renal ischemia in rats |
| topic | Acute Kidney Injury Fluid Therapy Colloids Hetastarch Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100002&tlng=en |
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