A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China
Abstract Background Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide more detailed analysis of 272 cases of EKC in 8 years, describe the dif...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-019-1266-z |
| _version_ | 1818643661456408576 |
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| author | Wenbo Hou Xuguang Sun Jun Feng Yang Zhang Zhiqun Wang |
| author_facet | Wenbo Hou Xuguang Sun Jun Feng Yang Zhang Zhiqun Wang |
| author_sort | Wenbo Hou |
| collection | DOAJ |
| description | Abstract Background Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide more detailed analysis of 272 cases of EKC in 8 years, describe the differences of the clinical features among different age groups, and establish new clinical grading criteria. Methods 272 individuals were reviewed (2011–2019) in Beijing China. All the patients were classified into 3 grades according to the new grading criteria. The typical clinical signs of EKC and the photographs of the multiple subepithelial corneal infiltrates (MSI) were collected and analyzed. The number of 3 grades among and within different age groups were compared. The incidence of the typical signs among and within different age groups were compared. The proportion of each region of the cornea involved by MSI were compared. Results No significant differences were detected among the 4 groups in terms of the number of mild, moderate and severe cases, no matter in all-patients analysis (P = 0.271) nor in acute-phase-patients analysis (P = 0.203). The proportion of the severe cases was the highest among all patients (P = 0.000). Among the incidence of the typical signs, corneal involvement was the most common accounting for 69.8% (P<0.05). The probability of central region involvement was significantly higher than that of pericentral region involvement (P = 0.015) and peripheral region involvement (P = 0.000). Conclusions Appropriate attention should be paid on EKC, because of the considerable proportion of severe cases, the high incidence of corneal lesion, and the high incidence of central region involvement of MSI. |
| first_indexed | 2024-12-17T00:02:30Z |
| format | Article |
| id | doaj.art-ffd810d84b1a4708bf40c4e5aab8f1a3 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-17T00:02:30Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-ffd810d84b1a4708bf40c4e5aab8f1a32022-12-21T22:11:02ZengBMCBMC Ophthalmology1471-24152019-12-011911710.1186/s12886-019-1266-zA 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, ChinaWenbo Hou0Xuguang Sun1Jun Feng2Yang Zhang3Zhiqun Wang4Eye Hospital, China Academy Of Chinese Medical SciencesDepartment Of Ocular Microbiology, Beijing Institute Of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityEye Hospital, China Academy Of Chinese Medical SciencesDepartment Of Ocular Microbiology, Beijing Institute Of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment Of Ocular Microbiology, Beijing Institute Of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityAbstract Background Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide more detailed analysis of 272 cases of EKC in 8 years, describe the differences of the clinical features among different age groups, and establish new clinical grading criteria. Methods 272 individuals were reviewed (2011–2019) in Beijing China. All the patients were classified into 3 grades according to the new grading criteria. The typical clinical signs of EKC and the photographs of the multiple subepithelial corneal infiltrates (MSI) were collected and analyzed. The number of 3 grades among and within different age groups were compared. The incidence of the typical signs among and within different age groups were compared. The proportion of each region of the cornea involved by MSI were compared. Results No significant differences were detected among the 4 groups in terms of the number of mild, moderate and severe cases, no matter in all-patients analysis (P = 0.271) nor in acute-phase-patients analysis (P = 0.203). The proportion of the severe cases was the highest among all patients (P = 0.000). Among the incidence of the typical signs, corneal involvement was the most common accounting for 69.8% (P<0.05). The probability of central region involvement was significantly higher than that of pericentral region involvement (P = 0.015) and peripheral region involvement (P = 0.000). Conclusions Appropriate attention should be paid on EKC, because of the considerable proportion of severe cases, the high incidence of corneal lesion, and the high incidence of central region involvement of MSI.https://doi.org/10.1186/s12886-019-1266-zEpidemic keratoconjunctivitisMultiple subepithelial corneal infiltrates |
| spellingShingle | Wenbo Hou Xuguang Sun Jun Feng Yang Zhang Zhiqun Wang A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China BMC Ophthalmology Epidemic keratoconjunctivitis Multiple subepithelial corneal infiltrates |
| title | A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China |
| title_full | A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China |
| title_fullStr | A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China |
| title_full_unstemmed | A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China |
| title_short | A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China |
| title_sort | 8 year retrospective clinical analysis of 272 patients of epidemic keratoconjunctivitis in beijing china |
| topic | Epidemic keratoconjunctivitis Multiple subepithelial corneal infiltrates |
| url | https://doi.org/10.1186/s12886-019-1266-z |
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