Discovery of 9<i>O</i>-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways

Discovery of 9<i>O</i>-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways

Twenty 9<i>O</i>-substituted palmatine derivatives were prepared and tested for their biological effect against collagen &#945;1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure&#8722;activity relationship (SAR) indicated that the introduction of a benzyl...

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Bibliographic Details
Main Authors: Tianyun Fan, Maoxu Ge, Zhihao Guo, Hongwei He, Na Zhang, Yinghong Li, Danqing Song
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
hepatic fibrosis
palmatine
structure−activity relationship
col1a1
tgf-β1/smads pathway
jak1/stat3 pathway
Online Access:https://www.mdpi.com/1420-3049/25/4/773

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