Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition

Abstract Background Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess the in vitro anticancer and P-glycoprotein inhibitory potential of extr...

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Bibliographic Details
Main Authors: Trevor Burger, Tsholofelo Mokoka, Gerda Fouché, Paul Steenkamp, Vanessa Steenkamp, Werner Cordier
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Cancer
P-glycoprotein
Solanum aculeastrum
Solamargine
Solasonine
Steroidal alkaloids
Online Access:http://link.springer.com/article/10.1186/s12906-018-2208-7

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