Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke
Amide proton transfer (APT) imaging is gaining attention as a relatively new in vivo molecular imaging technique that has higher sensitivity and spatial resolution than magnetic resonance spectroscopy imaging. APT imaging is a subset of the chemical exchange saturation transfer mechanism, which can...
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| Format: | Article |
| Language: | English |
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The Korean Society of Radiology
2016-12-01
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| Series: | 대한영상의학회지 |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2016.75.6.419 |
| _version_ | 1818270452173242368 |
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| author | Ji Eun Park Geon-Ho Jahng Ha-Kyu Jeong |
| author_facet | Ji Eun Park Geon-Ho Jahng Ha-Kyu Jeong |
| author_sort | Ji Eun Park |
| collection | DOAJ |
| description | Amide proton transfer (APT) imaging is gaining attention as a relatively new in vivo molecular imaging technique that has higher sensitivity and spatial resolution than magnetic resonance spectroscopy imaging. APT imaging is a subset of the chemical exchange saturation transfer mechanism, which can offer unique image contrast by selectively saturating protons in target molecules that get exchanged with protons in bulk water. In this review, we describe the basic concepts of APT imaging, particularly with regard to the benefit in clinics from the current literature. Clinical applications of APT imaging are described from two perspectives: in the diagnosis and monitoring of the treatment response in brain glioma by reflecting endogenous mobile proteins and peptides, and in the potential for stroke imaging with respect to tissue acidity. |
| first_indexed | 2024-12-12T21:10:30Z |
| format | Article |
| id | doaj.art-ffd97331db07477891ee25fb1fa9b258 |
| institution | Directory Open Access Journal |
| issn | 1738-2637 2288-2928 |
| language | English |
| last_indexed | 2024-12-12T21:10:30Z |
| publishDate | 2016-12-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | 대한영상의학회지 |
| spelling | doaj.art-ffd97331db07477891ee25fb1fa9b2582022-12-22T00:11:54ZengThe Korean Society of Radiology대한영상의학회지1738-26372288-29282016-12-01756419433https://doi.org/10.3348/jksr.2016.75.6.419Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and StrokeJi Eun Park0Geon-Ho Jahng1Ha-Kyu Jeong2Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, KoreaDepartment of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, KoreaPhilips Korea, Seoul, KoreaAmide proton transfer (APT) imaging is gaining attention as a relatively new in vivo molecular imaging technique that has higher sensitivity and spatial resolution than magnetic resonance spectroscopy imaging. APT imaging is a subset of the chemical exchange saturation transfer mechanism, which can offer unique image contrast by selectively saturating protons in target molecules that get exchanged with protons in bulk water. In this review, we describe the basic concepts of APT imaging, particularly with regard to the benefit in clinics from the current literature. Clinical applications of APT imaging are described from two perspectives: in the diagnosis and monitoring of the treatment response in brain glioma by reflecting endogenous mobile proteins and peptides, and in the potential for stroke imaging with respect to tissue acidity.https://doi.org/10.3348/jksr.2016.75.6.419magnetic resonance imagingamidesprotonsgliomastroke |
| spellingShingle | Ji Eun Park Geon-Ho Jahng Ha-Kyu Jeong Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke 대한영상의학회지 magnetic resonance imaging amides protons glioma stroke |
| title | Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke |
| title_full | Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke |
| title_fullStr | Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke |
| title_full_unstemmed | Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke |
| title_short | Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke |
| title_sort | amide proton transfer imaging in clinics basic concepts and current and future use in brain tumors and stroke |
| topic | magnetic resonance imaging amides protons glioma stroke |
| url | https://doi.org/10.3348/jksr.2016.75.6.419 |
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