Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer
Abstract With the discovery of bacterial symbiosis in the tissues of various cancers, the study of the tumor microbiome is attracting a great deal of attention. Anatomically, since the gastrointestinal tract, liver, and pancreas form a continuous ductal structure, the microbiomes in the digestive ju...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12658-8 |
| _version_ | 1818239267751591936 |
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| author | Shujiro Okuda Yuki Hirose Hayato Takihara Akiko Okuda Yiwei Ling Yosuke Tajima Yoshifumi Shimada Hiroshi Ichikawa Kazuyasu Takizawa Jun Sakata Toshifumi Wakai |
| author_facet | Shujiro Okuda Yuki Hirose Hayato Takihara Akiko Okuda Yiwei Ling Yosuke Tajima Yoshifumi Shimada Hiroshi Ichikawa Kazuyasu Takizawa Jun Sakata Toshifumi Wakai |
| author_sort | Shujiro Okuda |
| collection | DOAJ |
| description | Abstract With the discovery of bacterial symbiosis in the tissues of various cancers, the study of the tumor microbiome is attracting a great deal of attention. Anatomically, since the gastrointestinal tract, liver, and pancreas form a continuous ductal structure, the microbiomes in the digestive juices of these organs may influence each other. Here, we report a series of microbiome data in tumor-associated tissues such as tumor, non-tumor, and lymph nodes, and body fluids such as saliva, gastric juice, pancreatic juice, bile, and feces of patients with pancreatic or biliary tract cancers. The results show that the microbiome of tumor-associated tissues has a very similar bacterial composition, but that in body fluids has different bacterial composition which varies by location, where some bacteria localize to specific body fluids. Surprisingly, Akkermansia was only detected in the bile of patients with biliary tract cancer and its presence was significantly associated with the performance of external biliary drainage (P = 0.041). Furthermore, we found that tumor-associated tissues and body fluids in deep inner body are mostly inhabited by unidentified and uncharacterized bacteria, suggesting that such bacteria may be potential targets for precision therapy in the future. |
| first_indexed | 2024-12-12T12:54:50Z |
| format | Article |
| id | doaj.art-ffd98563183a4169b27c8e017be1efaa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T12:54:50Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ffd98563183a4169b27c8e017be1efaa2022-12-22T00:23:54ZengNature PortfolioScientific Reports2045-23222022-05-011211910.1038/s41598-022-12658-8Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancerShujiro Okuda0Yuki Hirose1Hayato Takihara2Akiko Okuda3Yiwei Ling4Yosuke Tajima5Yoshifumi Shimada6Hiroshi Ichikawa7Kazuyasu Takizawa8Jun Sakata9Toshifumi Wakai10Division of Bioinformatics, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Bioinformatics, Niigata University Graduate School of Medical and Dental SciencesDepartment of Medical Technology, Graduate School of Health Sciences, Niigata UniversityDivision of Bioinformatics, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental SciencesAbstract With the discovery of bacterial symbiosis in the tissues of various cancers, the study of the tumor microbiome is attracting a great deal of attention. Anatomically, since the gastrointestinal tract, liver, and pancreas form a continuous ductal structure, the microbiomes in the digestive juices of these organs may influence each other. Here, we report a series of microbiome data in tumor-associated tissues such as tumor, non-tumor, and lymph nodes, and body fluids such as saliva, gastric juice, pancreatic juice, bile, and feces of patients with pancreatic or biliary tract cancers. The results show that the microbiome of tumor-associated tissues has a very similar bacterial composition, but that in body fluids has different bacterial composition which varies by location, where some bacteria localize to specific body fluids. Surprisingly, Akkermansia was only detected in the bile of patients with biliary tract cancer and its presence was significantly associated with the performance of external biliary drainage (P = 0.041). Furthermore, we found that tumor-associated tissues and body fluids in deep inner body are mostly inhabited by unidentified and uncharacterized bacteria, suggesting that such bacteria may be potential targets for precision therapy in the future.https://doi.org/10.1038/s41598-022-12658-8 |
| spellingShingle | Shujiro Okuda Yuki Hirose Hayato Takihara Akiko Okuda Yiwei Ling Yosuke Tajima Yoshifumi Shimada Hiroshi Ichikawa Kazuyasu Takizawa Jun Sakata Toshifumi Wakai Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer Scientific Reports |
| title | Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| title_full | Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| title_fullStr | Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| title_full_unstemmed | Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| title_short | Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| title_sort | unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer |
| url | https://doi.org/10.1038/s41598-022-12658-8 |
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