A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation

A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation

T-cell activation is a pivotal process of the adaptive immune response with 3′,5′-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function. It governs crucial control over T-cell differentiation and production of pro-inflammatory cytokines, such as IFN-γ. Intriguing...

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Bibliographic Details
Main Authors: Marie Bielenberg, Roberta Kurelic, Stefan Frantz, Viacheslav O. Nikolaev
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
cAMP
phosphodiesterases
T-cell activation
T-cell subsets
cGMP-to-cAMP crosstalk
PDE2A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1365484/full

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